A Rare Presentation of Alveolar Soft Part Sarcoma in the Bladder

Area of Science:

• Oncology
• Uropathology
• Genetics

Background:

• Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma (<1% of all sarcomas).
• ASPS is characterized by the t(X;17)(p11;q25) translocation and typically affects younger individuals in the extremities.
• Bladder ASPS is exceptionally rare, especially as a second primary malignancy.

Purpose of the Study:

• To report a rare case of alveolar soft part sarcoma (ASPS) of the bladder.
• To highlight diagnostic challenges and therapeutic strategies for bladder ASPS.
• To emphasize the importance of long-term surveillance for this rare malignancy.

Main Methods:

• Histopathological analysis
• Immunohistochemistry
• Molecular diagnostics
• Partial cystectomy

Main Results:

• Diagnosis of bladder ASPS confirmed via histopathology, immunohistochemistry, and molecular diagnostics.
• Patient underwent successful partial cystectomy with clear surgical margins.
• No recurrence observed 38 months post-resection.

Conclusions:

• Bladder ASPS is a rare entity requiring a multidisciplinary diagnostic approach.
• Surgical resection with clear margins is a viable treatment strategy.
• Long-term surveillance is crucial for patients with bladder ASPS.