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Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...

Amyloid Fibrils

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...

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Related Experiment Video

Updated: Jun 27, 2026

Use of Two Dimensional Semi-denaturing Detergent Agarose Gel Electrophoresis to Confirm Size Heterogeneity of Amyloid or Amyloid-like Fibers

Use of Two Dimensional Semi-denaturing Detergent Agarose Gel Electrophoresis to Confirm Size Heterogeneity of Amyloid or Amyloid-like Fibers

Published on: April 26, 2018

Light Chain (AL) Amyloidosis Masquerading as Scleroderma: A Diagnostic Challenge.

Kriti Dhamija¹, Rahim A Jiwani², Arjun Lakshaman²

¹Medicine Institute, Allegheny Health Network, Pittsburgh, PA 15212, USA.

Journal of Hematology

|June 12, 2025

Summary

This summary is machine-generated.

Diagnosing amyloid light chain (AL) amyloidosis can be challenging due to nonspecific symptoms. Comprehensive testing, including serum-free light chains, is crucial for timely diagnosis and effective management of this systemic disease.

Area of Science:

Internal Medicine
Cardiology
Rheumatology

Background:

Systemic amyloidosis presents with diverse, nonspecific symptoms, often mimicking other conditions.
This diagnostic challenge can lead to delayed recognition and treatment.

Keywords:

Amyloidosis Congo red staining Free light chain Smoldering multiple myeloma

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