Major Cardiovascular and Renal Complications in IgA Vasculitis: Insights from a Federated Health Research Network

IgA Vasculitis (IgAV) is an immune-mediated condition with limited data on its long-term prognosis in adults. This study utilized the federated TriNetX network to evaluate the incidence of cardiac, renal, and vascular complications in adults diagnosed with IgAV. After propensity score matching, 12,506 patients with IgAV and 12,506 controls were analyzed. Over 6-month, 1-year, and 3-year periods, patients with IgAV had significantly higher risks of myocardial infarction, atrial fibrillation, stroke, pulmonary embolism, venous thromboembolism, chronic kidney disease, and end-stage renal disease compared to controls. Chronic kidney disease was the most common complication, with a 3-year risk of 8.6% and the highest absolute and relative risk difference. These findings suggest that adults with IgAV may be at increased risk for serious renal and cardiovascular complications, underscoring the need for further study to determine best practices for long term monitoring and management to mitigate morbidity associated with the disease.