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Updated: Jun 14, 2025
Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
Published on: December 8, 2014
Discordance in Clinical Indicators With Sequential Fecal Microbiota Transplantation: A Case of Fulminant
Peter Bhandari1, Reanay Berezovskiy2, Salima Makhani1
1Division of Gastroenterology, Morristown Medical Center, Atlantic Health System, Morristown, NJ.
Abstract:
Fulminant Clostridioides difficile infection (CDI) is a rare, severe type of CDI, often associated with extended hospitalizations, significant healthcare costs, and elevated mortality rates. Fecal microbiota transplantation remains an effective treatment modality for patients with fulminant CDI, with high cure rates reported after multiple treatments. Stool frequency, pseudomembrane resolution, and inflammatory markers are routinely monitored to evaluate disease severity and treatment responsiveness. Our case highlights a discordance in these indicators and demonstrates C-reactive protein as an important marker in assessing residual colitis and disease resolution. Comprehensive scoring systems should consider incorporating C-reactive protein and other biomarkers to optimize CDI management.
Insights
Fulminant Clostridioides difficile infection (CDI) is severe. C-reactive protein (CRP) is a key marker for assessing residual colitis and treatment success in fulminant CDI cases.
Area of Science:
- Infectious Diseases
- Gastroenterology
- Microbiology
Background:
- Fulminant Clostridioides difficile infection (CDI) is a severe condition with high mortality and healthcare costs.
- Fecal microbiota transplantation (FMT) is an effective treatment for fulminant CDI, often requiring multiple sessions.
- Standard monitoring includes stool frequency, pseudomembrane resolution, and inflammatory markers.
