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Retinoblastoma research trends from 1980 to 2023: a 44-year bibliometric study
Yun Zhao1, Yining Wang1, Yuchuan Wang1,2,3
1Department of Ophthalmology, Tianjin Eye Hospital, Tianjin, China.
Frontiers in Oncology
|June 12, 2025
Summary
This study analyzes 44 years of retinoblastoma (RB) research, revealing the US and China as leaders. Future hotspots include liquid biopsy and advanced chemotherapy techniques for this childhood eye cancer.
Area of Science:
- Ophthalmology
- Pediatric Oncology
- Bibliometrics
Background:
- Retinoblastoma (RB) is the most common intraocular malignancy in children, posing significant risks to vision and life.
- Timely treatment is crucial for managing this aggressive childhood eye cancer.
Purpose of the Study:
- To analyze global research trends in retinoblastoma (RB) from 1980 to 2023.
- To compare the contributions of different countries, institutions, and authors in RB research.
- To identify emerging research hotspots and future directions in the field of retinoblastoma.
Main Methods:
- Bibliometric analysis of 4156 RB-related publications from the Web of Science database (1980-2023).
- Utilized VOSviewer, R software, Bibliometrix, Origin 2024, and CiteSpace for data analysis and visualization.
- Classified publications by year, country/region, institution, journal, author, and keywords to map research landscape.
Main Results:
- A significant increase in RB publications, from 13 in 1980 to 237 in 2023.
- The United States leads with 1662 publications (39.99%), followed by China (539) and India (377).
- Thomas Jefferson University is the most prolific institution; key journals include *Investigative Ophthalmology & Visual Science*, *British Journal of Ophthalmology*, and *Ophthalmology*.
Conclusions:
- The US, China, India, Canada, and Germany are leading RB research globally.
- Prominent institutions and researchers continue to drive advancements in retinoblastoma.
- Liquid biopsy, intra-arterial chemotherapy, and intravitreal chemotherapy represent future research frontiers.
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