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T cell exhaustion in pediatric B-ALL: current knowledge and future perspectives

Tanmaya Atre1, Gregor S D Reid1,2

  • 1Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital Research Institute, Vancouver, BC, Canada.

Frontiers in Immunology
|June 12, 2025
PubMed
Summary

T cell exhaustion, marked by inhibitory receptors, contributes to pediatric B-cell acute lymphoblastic leukemia (B-ALL) progression. Targeting this exhaustion may enhance immune activity against B-ALL.

Keywords:
T cell exhaustion (Tex)bispecific T cell engager (BiTE)chimeric antigen receptor (CAR T)immune checkpoint inhibitionpediatric B cell precursor acute lymphoblastic leukemia

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