Comparison of Helicobacter pylori Eradication Rates Using Standard Triple Therapy and Sequential Therapy

Area of Science:

• Gastroenterology
• Infectious Diseases
• Pharmacology

Background:

• Standard triple therapy (STT) for Helicobacter pylori eradication (HPE) faces increasing treatment failures due to antibiotic resistance.
• Sequential therapy (SQ) is an alternative approach to combat resistance and improve HPE outcomes.

Purpose of the Study:

• To compare the efficacy, compliance, and safety of 7-day STT versus 10-day SQ for HPE.
• To evaluate the effectiveness of these therapies in a real-world clinical setting.

Main Methods:

• A chronological cohort study analyzed 789 patients undergoing HPE treatment.
• Patients received either 7-day STT (n=378) or 10-day SQ (n=411).
• Eradication rates, compliance, and adverse events were compared between groups.

Main Results:

• SQ achieved a significantly higher eradication rate (84.7%) than 7-day STT (74.1%) as first-line therapy (p<0.001).
• Adverse events were more frequent with SQ (17.5%) versus STT (11.1%) (p=0.01), but compliance was similar (98.1% vs. 96.8%).
• Overall eradication rates did not differ significantly between STT and SQ (98.3% vs. 97.4%).

Conclusions:

• Sequential therapy (SQ) is more effective than 7-day standard triple therapy (STT) for initial Helicobacter pylori eradication.
• SQ is a potential replacement for STT in treatment-naïve patients.
• Further research may explore optimizing SQ regimens to mitigate adverse events.