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Updated: Jun 13, 2025

Dissolution Dynamic Nuclear Polarization Instrumentation for Real-time Enzymatic Reaction Rate Measurements by NMR
Published on: February 23, 2016
In Silico Design of Methyl-Driven Overhauser Dynamic Nuclear Polarization Agents
Scott A Southern1, Georgia A Zissimou2, Dragos F Flesariu2
1Chemical and Biological Sciences Division, Ames National laboratory, Ames, Iowa 50011, United States.
None:
Overhauser effect (OE) dynamic nuclear polarization (DNP) has drawn attention owing to its enhanced performance at ultrahigh magnetic fields. The lack of design principles has, nevertheless, limited the development of OE polarizing agents when compared to those used for cross-effect DNP. We measured the 19F OE DNP performance of a series of CF3-functionalized Blatter-type radicals. Using density functional theory calculations, we accurately predict the methyl-driven OE performance, paving the way for computer-aided design of optimized OE DNP polarizing agents.
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