Spectroelectrochemical Fiber-Optic Sensor Based on Localized Surface Plasmon Resonance for Simultaneous...

Area of Science:

• Nanotechnology
• Analytical Chemistry
• Biomedical Engineering

Background:

• Localized surface plasmon resonance (LSPR) offers sensitive optical detection.
• Electrochemical sensing provides quantitative analysis of redox-active species.
• Fiber-optic sensors enable remote and multiplexed measurements.

Purpose of the Study:

• To develop a novel sensor combining electrochemistry, LSPR, and fiber-optic sensing.
• To demonstrate two distinct sensing mechanisms for analyte detection.
• To validate the sensor's performance using model analytes and for biodetection.

Main Methods:

• Fabrication of an indium tin oxide (ITO)-coated multimodal optical fiber with immobilized gold nanoparticles.
• Development of LSPR peak wavelength shift detection coupled with electrochemical oxidation-reduction.
• Implementation of potential scanning for refractive index change detection and biodetection via avidin-biotin interaction.

Main Results:

• Demonstrated a linear relationship between LSPR peak shift and analyte concentration for electrochemical sensing.
• Successfully detected refractive index changes in sucrose solutions.
• Achieved specific biodetection of NeutrAvidin using the avidin-biotin interaction.

Conclusions:

• The developed sensor effectively integrates electrochemistry, LSPR, and fiber-optic sensing.
• The sensor exhibits versatile detection capabilities for both chemical analytes and biomolecules.
• This novel platform holds promise for advanced sensing applications.