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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
454
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  11. Predictive Value Of Short-term Steroid Intraocular Pressure Elevation Testing For Long-term Steroid Intraocular Pressure Elevation In Diabetic Macular Edema Treatment

Predictive value of short-term steroid intraocular pressure elevation testing for long-term steroid intraocular pressure elevation in diabetic macular edema treatment

Catarina Pestana Aguiar1, João Alves Ambrósio2, Vítor Miranda2

  • 1Unidade Local de Saúde Entre Douro e Vouga, Santa Maria da Feira, Portugal. catarina.pestana.aguiar@gmail.com.

International Ophthalmology
|June 12, 2025

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Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
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Use of Rabbit Eyes in Pharmacokinetic Studies of Intraocular Drugs
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Published on: July 23, 2016

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View abstract on PubMed

Summary
This summary is machine-generated.

Intraocular pressure (IOP) elevation after intravitreal triamcinolone acetonide (TA) testing does not predict IOP response to fluocinolone acetonide (FAc) implants for diabetic macular edema. A prior TA challenge may not reliably indicate FAc implant outcomes.

Area of Science:

  • Ophthalmology
  • Endocrinology
  • Pharmacology

Background:

  • Diabetic macular edema (DME) management often involves corticosteroids.
  • Intraocular pressure (IOP) elevation is a known side effect of intravitreal steroids.
  • Predicting individual steroid response is crucial for treatment selection.

Purpose of the Study:

  • To determine if IOP elevation after intravitreal triamcinolone acetonide (TA) predicts IOP response to fluocinolone acetonide (FAc) implants in DME patients.
  • To analyze the correlation between IOP changes following two different intravitreal steroid treatments.

Main Methods:

  • Retrospective observational cohort study of 28 eyes.
  • Patients received intravitreal TA followed by a FAc implant.
  • IOP measured before and after both treatments; steroid response defined as IOP > 21 mmHg.
Keywords:
Fluocinolone acetonide implantIntraocular pressureIntravitreal injectionsMacular diabetic edema

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Main Results:

  • No statistically significant correlation found between TA-induced IOP elevation and subsequent FAc-induced IOP changes.
  • Six eyes showed a steroid response to TA; none of these responded to FAc.
  • Six additional eyes developed a steroid response to the FAc implant.

Conclusions:

  • The predictive value of a short-acting steroid (TA) challenge for long-acting steroid (FAc) implant response was not evident.
  • Relying on TA testing to predict FAc implant outcomes may not be useful.
  • Consideration of prolonged steroid implants may be beneficial despite risks of relapse.
Triamcinolone acetonide