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Related Concept Videos

Regulation of Heart Rates01:31

Regulation of Heart Rates

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The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
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The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
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Tumor Progression02:07

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Ischemic Heart Disease: Overview01:17

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  9. Predictive And Prognostic Markers
  11. The Prognostic And Protective Roles Of Heart-rate Variability In Glioblastoma: Making Gbm Less Vague

The prognostic and protective roles of heart-rate variability in glioblastoma: making GBM less vague

Yori Gidron1, Niv Katan2, Nour Mansour2

  • 1Faculty of Social Welfare and Sciences, University of Haifa, Haifa, Israel.

Journal of Neuro-Oncology
|June 12, 2025

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Author Spotlight: Advancing the Study of Brain-Heart Interplay with a Comprehensive EEGLAB Plugin for Multimodal Signal Analysis

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Calculating Heart Rate Variability from ECG Data from Youth with Cerebral Palsy During Active Video Game Sessions
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Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
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Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

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View abstract on PubMed

Summary
This summary is machine-generated.

Vagal nerve activity, measured by heart rate variability (HRV), shows prognostic value in younger glioblastoma patients. Higher HRV is linked to longer overall survival, suggesting it could be a therapeutic target.

Area of Science:

  • Neuroscience
  • Oncology
  • Cardiology

Background:

  • Vagal nerve activity influences cancer prognosis.
  • Glioblastoma is an aggressive brain tumor with limited treatment options.

Purpose of the Study:

  • To investigate the prognostic significance of vagal nerve activity in newly diagnosed glioblastoma patients.
  • To determine if heart rate variability (HRV) can predict overall survival (OS) in this population.

Main Methods:

  • Retrospective analysis of 88 glioblastoma patients undergoing surgery or biopsy.
  • Vagal nerve activity assessed via heart rate variability (HRV) from pre-operative ECGs.
  • Overall survival (OS) as the primary endpoint, analyzed with respect to HRV and other prognostic factors.

Main Results:

Keywords:
GlioblastomaHeart rate variabilityPrognosisVagal activity

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Calculating Heart Rate Variability from ECG Data from Youth with Cerebral Palsy During Active Video Game Sessions
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  • HRV independently predicted OS in younger patients (≤65 years).
  • Patients with high HRV had significantly longer OS (20.2 months) compared to those with low HRV (13.2 months).
  • HRV moderated the prognostic impact of extent of resection and Karnofsky Performance Status (KPS).

Conclusions:

  • Vagal nerve activity, indexed by HRV, demonstrates clinical and prognostic value in newly diagnosed glioblastoma.
  • HRV may serve as a novel therapeutic target for glioblastoma, warranting further prospective investigation.