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  11. Polyphenol Profiles, Antioxidant And Anti-inflammatory Activities Of Hydromethanolic Extract Of Lepidium Sativum Linn Seeds

Polyphenol profiles, antioxidant and anti-inflammatory activities of hydromethanolic extract of Lepidium sativum Linn seeds

Nesrine Ouda Amari1, Fatiha Missoun1, Ouafa Rebai2

  • 1Department of Biotechnology, University of Abdelhamid Ibn Badis, Mostaganem, Algeria.

Natural Product Research
|June 12, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

Lepidium sativum (garden cress) seeds exhibit significant anti-inflammatory and antioxidant properties. This study demonstrates its potential as a natural therapeutic agent for inflammation.

Area of Science:

  • Pharmacology
  • Natural Products Chemistry

Background:

  • Inflammation is a complex biological response implicated in various diseases.
  • Natural products are increasingly investigated for therapeutic potential.
  • Lepidium sativum (garden cress) is traditionally used but requires scientific validation.

Purpose of the Study:

  • To evaluate the anti-inflammatory and antioxidant activities of hydromethanolic Lepidium sativum seed extract in a mouse model.
  • To identify key phytochemical constituents contributing to these activities.

Main Methods:

  • Carrageenan-induced paw edema model in mice for anti-inflammatory assessment.
  • 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay for antioxidant activity.
  • High-Performance Liquid Chromatography-Diode-Array Detector (HPLC-DAD) for phytochemical analysis.
Keywords:
Lepidium sativumantioxidative activityinflammationpolyphenols

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Main Results:

  • The extract demonstrated significant antioxidant activity (0.38 ± 0.005 µg/mL) comparable to ascorbic acid.
  • Oral administration of L. sativum extract reduced carrageenan-induced paw inflammation by 24.96% and 14.17% at 150 and 300 mg/kg, respectively.
  • HPLC-DAD analysis identified gallic acid, syringic acid, hydroxycinnamic acid, rutin, and apigenin in the extract.

Conclusions:

  • Lepidium sativum seed extract possesses notable anti-inflammatory and antioxidant effects.
  • The identified polyphenolic compounds likely contribute to the observed bioactivities.
  • L. sativum shows promise as a natural therapeutic agent for inflammatory conditions.