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Importance of potential prothrombotic state markers in Behçet's disease and correlation with vascular ultrasound

Hazan Karadeniz1,2, Tunjay Mammadov3, Mahi Nur Cerit3

  • 1Division of Rheumatology, GülhaneTraining and Research Hospital, Ankara, Turkey. drhazankaradeniz@hotmail.com.

Irish Journal of Medical Science
|June 12, 2025
PubMed

Insights

Growth differentiation factor-15 (GDF-15) and citrullinated histone H3 (CitH3) are elevated in Behçet's disease (BD) patients with vascular issues. These markers may indicate thrombosis and vascular involvement in BD.

Area of Science:

  • Vascular Biology
  • Rheumatology
  • Biochemistry

Background:

  • Behçet's disease (BD) is a chronic inflammatory disorder with a high risk of vascular complications.
  • Prothrombotic markers may play a role in the pathogenesis of vascular involvement in BD.

Purpose of the Study:

  • To investigate the association between serum levels of P-selectin, citrullinated histone H3 (CitH3), and growth differentiation factor-15 (GDF-15) and vascular thickness in BD patients.
  • To identify potential biomarkers for vascular involvement and thrombosis in Behçet's disease.

Main Methods:

  • A comparative study involving 56 BD patients and 19 healthy controls.
  • Assessment of B-mode ultrasound for vascular measurements and biochemical analysis of prothrombotic markers.
  • Logistic regression and ROC curve analysis to determine factors influencing thrombosis.

Main Results:

  • BD patients exhibited higher serum levels of P-selectin, CitH3, and GDF-15 compared to healthy controls.
  • CitH3 and GDF-15 levels were significantly elevated in BD patients with vascular involvement.
  • GDF-15 levels correlated significantly with femoral vein thickness in vascular BD patients.

Conclusions:

  • GDF-15 and CitH3 show promise as biomarkers for detecting vascular involvement and thrombosis in Behçet's disease.
  • These markers could aid in the early identification and management of vascular complications in BD.
Abstract

Keywords:
Behçet’s diseaseCitrullinated histone H3Growth differentiation factor-15P-selectinThrombosis

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