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In Vivo Imaging of Reactive Oxygen Species in a Murine Wound Model
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Prussian Blue Nanozyme-Functionalized Hydrogel with Self-Enhanced Redox Regulation for Accelerated Wound Healing.
Kun Lu1, He Ding1, Mengmeng Long1
1Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210009, P. R. China.
ACS Applied Materials & Interfaces
|June 12, 2025
Summary
This study developed a novel hydrogel wound dressing using Prussian blue nanozymes (PBNZs) that enhances its own enzyme-like activity. This self-enhanced dressing effectively regulates reactive oxygen species (ROS) and promotes skin defect healing.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Wound Healing Research
Background:
- Reactive oxygen species (ROS) accumulation and inflammation impede wound repair.
- Nanozyme-functionalized hydrogels are explored for ROS regulation in wound healing.
- Long-term effectiveness and enhanced enzyme activity are crucial for wound dressings.
Purpose of the Study:
- To construct a hydrogel wound dressing with self-enhanced enzyme-like activity using Prussian blue nanozymes (PBNZs).
- To investigate the catalytic mechanisms and ROS regulation capabilities of PBNZs-based hydrogels.
- To evaluate the efficacy of the developed hydrogel in promoting skin defect healing.
Main Methods:
- Fabrication of hydrogel wound dressings functionalized with PBNZs.
- Investigation of the electron transfer catalytic mechanism and enzyme-like activity enhancement of PBNZs.
- Assessment of ROS scavenging ability and wound healing promotion in skin defect models.
- Verification of stable PBNZ fixation within the hydrogel matrix.
Main Results:
- The PBNZs-functionalized hydrogel demonstrated self-enhanced enzyme-like activity.
- Stable fixation of PBNZs within the hydrogel prevented release and ensured sustained activity.
- The hydrogel effectively regulated ROS in the wound microenvironment.
- Significant promotion of skin defect healing was observed in animal models.
Conclusions:
- PBNZs-based hydrogels possess intrinsic properties suitable for advanced wound healing applications.
- The self-enhanced enzyme-like activity of the hydrogel dressing leads to superior ROS regulation.
- This study provides valuable insights into designing advanced wound dressings with enhanced catalytic functions for accelerated healing.
