Cancer in persons diagnosed with facial nerve paresis: A hospital-based cohort study in Denmark
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View abstract on PubMed
Summary
This summary is machine-generated.Facial nerve palsy (FNP) is linked to elevated cancer risks, particularly nervous system and head/neck cancers within a year. Persistent elevated risks for specific cancers suggest metastatic disease plays a key role in FNP.
Area Of Science
- Oncology
- Neurology
- Epidemiology
Background
- Neoplasms can cause facial nerve paresis or palsy (FNP) through compression or infiltration.
- Limited evidence exists for cancers outside the head, neck, and nervous system in FNP patients.
Purpose Of The Study
- To examine overall and site-specific cancer rates in patients diagnosed with FNP.
- To investigate cancer risks associated with FNP over a 29-year period in Denmark.
Main Methods
- Hospital-based cohort study in Denmark (1994-2022).
- Identified FNP cases from inpatient, outpatient, and emergency room visits.
- Calculated absolute risks (AR) and standardized incidence ratios (SIR) for cancers diagnosed <1 year and ≥1 year after FNP.
Main Results
- 27,147 FNP diagnoses recorded.
- Cancers diagnosed <1 year post-FNP showed elevated SIR for nervous system (14.7) and head/neck (8.37).
- Cancers diagnosed ≥1 year post-FNP showed persistent elevated SIR for salivary gland (2.43), brain (1.48), liver (2.02), and anus (1.94).
Conclusions
- Persistently elevated cancer rates observed in FNP patients compared to the general population.
- Metastatic disease is implied as a significant underlying cause of FNP.
- Further research into cancer stage associations with FNP is warranted.
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