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Updated: Jun 14, 2025

A Protocol for Genetic Induction and Visualization of Benign and Invasive Tumors in Cephalic Complexes of Drosophila melanogaster
Published on: September 11, 2013
"Cancer progression through systemic signaling viewed from Drosophila"
Masato Enomoto1, Shizue Ohsawa2
1Laboratory of Dynamic Biology, Department of Integrative Vascular Biology, University of Fukui, 23-3, Matsuoka-shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan.
None:
Cancers develop through local interactions between tumor cells and neighboring cells within the tissue micro environment, while distinct organs regulate cancer progression and suppression via systemic factors. Recent studies in Drosophila have revealed systemic signaling pathways that influence tumor development. This review summarizes the mechanisms by which organ-derived molecules remotely trigger tumor growth and suppression. Additionally, we discuss how tumors dysregulate various organ systems, leading to animal mortality.
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