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Updated: Jun 14, 2025

Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
Published on: October 4, 2019
NF-YB-driven expression of long non-coding RNA linc01811 inhibiting glioma tumorigenesis by regulating miR-4635/NF-YB
Le Zhang1, Shupeng Sun2, Qin Wang1
1Huanhu Hospital Affiliated to Tianjin Medical University, Tianjin, China; Department of Clinical Laboratory, Tianjin Huanhu Hospital, Tianjin, China.
Abstract:
Glioma, the most common malignant tumor of the central nervous system, is regulated by long non-coding ribonucleic acids (lncRNAs). This study reported that linc01811 is expressed at low levels in gliomas and inhibits glioma tumorigenesis by regulating the miR-4635-nuclear transcription factor Y subunit beta (NF-YB) axis. MiR-4635 is identified as a direct target of linc01811 and can specifically target the 3' untranslated region of NF-YB and consequently downregulate its expression. As a transcription factor, NF-YB binds to the linc01811 promoter, thereby activating its expression. Overall, this study identified a tumor suppressor lncRNA that inhibits glioma progression via the miR-4635/NF-YB feedback loop, highlighting a potential axis for diagnostic and therapeutic targeting in glioma.
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