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Updated: Jun 14, 2025
13:56
Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract
Published on: November 28, 2012
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A real-world population-based study on the association between cataracts and antipsychotics
Moiz Lakhani1, Angela T H Kwan1, Emaan Chaudry2
1Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada; Brain and Cognition Discovery Foundation, Toronto, ON, Canada.
Summary
First-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs) may be linked to cataract development. Chlorpromazine and quetiapine showed higher reporting odds for cataracts in a real-world safety analysis.
Area of Science:
- Pharmacovigilance and drug safety research.
- Ophthalmology and adverse drug event analysis.
Background:
- The association between antipsychotic medications and cataract development remains unclear.
- Real-world data is crucial for understanding drug safety profiles.
Purpose of the Study:
- To investigate the potential association between first-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs) and cataract development.
- To conduct a disproportionality analysis of cataract adverse events in individuals exposed to antipsychotics.
Main Methods:
- A population-based, observational pharmacovigilance study using the U.S. Food and Drug Administration Adverse Event Reporting System (2003-2024).
- Analysis of cataract reports associated with FGAs and SGAs using OpenVigil 2.1, calculating reporting odds ratios (RORs) and information components (IC).
Main Results:
- Chlorpromazine and quetiapine demonstrated significantly higher odds of cataract reporting compared to other drugs.
- Increased cataract reporting was observed for chlorpromazine in females and quetiapine in both sexes and across age groups.
- No significantly higher reporting odds for cataracts were found for the majority of FGAs and SGAs studied.
Conclusions:
- Cataract development was disproportionately reported with the use of specific FGAs and SGAs, notably chlorpromazine and quetiapine.
- While causality cannot be confirmed, these findings highlight the need for vigilance.
- Regular ocular monitoring is recommended for patients prescribed antipsychotic medications.
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