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Related Concept Videos

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Medical Microbiology
  9. Medical Mycology
  11. Pulmonary Aspergillosis: Epidemiology And Unresolved Diagnostic Challenges - Insights From A Two-year Retrospective Cohort Study In Marseille.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Medical Microbiology
  9. Medical Mycology
  11. Pulmonary Aspergillosis: Epidemiology And Unresolved Diagnostic Challenges - Insights From A Two-year Retrospective Cohort Study In Marseille.

Related Experiment Video

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
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Pulmonary Aspergillosis: Epidemiology and unresolved diagnostic challenges - insights from a two-year retrospective cohort study in Marseille.

Thi Quynh Pham1, Léa Delorme2, Sébastien Cortaredona3

  • 1Aix Marseille Univ, SSA, RITMES, Marseille, France; IHU-Méditerranée Infection, Marseille, France.

Respiratory Medicine
|June 12, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

This study reveals significant rates of Aspergillus-related lung diseases, including invasive pulmonary aspergillosis (IPA) and chronic pulmonary aspergillosis (CPA), with high mortality. Gaps in diagnosing allergic bronchopulmonary aspergillosis (ABPA) require improved clinical practice.

Keywords:
Aspergillus-specific IgEAspergillus-specific IgGDiagnosisEpidemiology

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Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Pulmonology

Background:

  • Aspergillus species cause various lung diseases, including invasive pulmonary aspergillosis (IPA), chronic pulmonary aspergillosis (CPA), and allergic bronchopulmonary aspergillosis (ABPA).
  • Host immune status influences disease presentation and severity.
  • Accurate diagnosis and management are crucial for patient outcomes.

Purpose of the Study:

  • To evaluate the epidemiology and clinical diagnosis of Aspergillus-related lung diseases.
  • To assess diagnostic challenges and clinical practice gaps at the University Hospital of Marseille (AP-HM).

Main Methods:

  • Retrospective cohort study of patients treated at AP-HM from January 2022 to December 2023.
  • Integration of Aspergillus-specific serologic tests (IgG, IgE) and galactomannan antigen (GM) testing with clinical and imaging data.
Galactomannan
Pulmonary aspergillosis
  • Application of standard diagnostic criteria for IPA, CPA, and ABPA.

    • Main Results:

    • Identified 1.9% IPA, 0.6% CPA, and 2.6% ABPA cases among tested patients.
    • Biotherapy agents (tocilizumab, oblinutuzumab) emerged as potential IPA risk factors.
    • Noted significant underdiagnosis and undertreatment of ABPA, with only 10 of 46 cases treated.
    • Reported high 3-month mortality rates: 46.7% for IPA and 13.3% for CPA.
    • Observed 13% exacerbation rate in treated ABPA patients despite therapy.

    Conclusions:

    • Aspergillus-related lung diseases are prevalent, with high mortality in IPA and CPA.
    • Discrepancies in ABPA diagnosis indicate a need for enhanced diagnostic algorithms.
    • Improved clinical practice and diagnostic guidelines are essential for managing these fungal infections.