Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Highly Selective and Modular Assembly of Densely Substituted Tetrahydrofurans.

Journal of the American Chemical Society·2026
Same author

Pterostilbene ameliorates benzo[b]fluoranthene-induced lung injury by suppressing Toll-like receptor 4/nuclear factor kappa-B pathway and mitochondria-mediated apoptosis.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2026
Same author

A Dual-Channel NIR Fluorescent Probe for Self-Calibrated Ratiometric Imaging and In Vivo Discrimination of Malignant Tumors via Alkaline Phosphatase Activity.

Analytical chemistry·2026
Same author

Identification of Key Genes and Clinical Feature Analyses of Epidermal Growth Factor Receptor Mutations in Lung Adenocarcinoma.

Genetic testing and molecular biomarkers·2026
Same author

Astragaloside IV enhances autophagy to suppress endoplasmic reticulum stress and pyroptosis after spinal cord injury.

Cellular signalling·2026
Same author

Endoplasmic reticulum-targeted photodynamic therapy synergizes with rapamycin to induce autophagic cancer cell death.

Acta biomaterialia·2026

Related Experiment Video

Updated: Jun 14, 2025

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

3.0K

A Self-Assembling Chimeric Peptide Gear-Set with "Three-in-One" Function for Precision Photodynamic Therapy.

Qishu Jiao1, Tingting Zhang2, Shuyao Zhou2

  • 1Department of Chemistry, China Pharmaceutical University, Nanjing 210009, China; Department of Urology, Urologic Surgery Center, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, China.

Acta Biomaterialia
|June 12, 2025
PubMed
Summary

A novel chimeric peptide nanoplatform, PpIX-1-DG, offers precision photodynamic therapy with auto-activation, cascade amplification, and self-reporting capabilities for enhanced cancer treatment and real-time monitoring.

Keywords:
Drug deliveryPeptidePhotodynamic therapySelf-assemblyTheranostics

More Related Videos

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.2K
Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
05:24

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Published on: September 6, 2024

1.1K

Related Experiment Videos

Last Updated: Jun 14, 2025

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
11:04

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

3.0K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.2K
Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility
05:24

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Published on: September 6, 2024

1.1K

Area of Science:

  • Biomedical Engineering
  • Nanomedicine
  • Cancer Therapy

Background:

  • Smart drug delivery systems are crucial for personalized cancer treatment, requiring tumor-specific activation and real-time monitoring.
  • Existing therapies often lack integrated mechanisms for precise activation and efficacy tracking.

Purpose of the Study:

  • To design and evaluate a novel chimeric peptide, PpIX-1-DG, for precision photodynamic therapy with integrated auto-activation, cascade amplification, and self-reporting features.
  • To demonstrate the therapeutic efficacy and monitoring capabilities of PpIX-1-DG in cancer treatment.

Main Methods:

  • Self-assembly of PpIX-1-DG into nanoparticles responsive to tumor microenvironment signals (GSH).
  • In vitro and in vivo evaluation of nanoparticle-mediated gemcitabine release, caspase-3 activation, ROS generation, and apoptosis induction.
  • Real-time monitoring of therapeutic response via PpIX-1-DG fluorescence.

Main Results:

  • PpIX-1-DG nanoparticles demonstrated targeted gemcitabine release in response to elevated GSH levels, activating caspase-3.
  • Caspase-3 activation led to the release of photosensitive PpIX-1, generating ROS upon photoirradiation for enhanced apoptosis.
  • The system exhibited a cascade amplification effect, increasing therapeutic efficacy and enabling real-time fluorescence monitoring of treatment progress.
  • Intravenous administration showed significant antitumor efficacy with minimal systemic toxicity.

Conclusions:

  • The developed "three-in-one" chimeric peptide nanoplatform (PpIX-1-DG) enables precision photodynamic therapy with synchronous therapeutic monitoring.
  • This approach holds significant potential for improving cancer treatment outcomes and offers a new paradigm for therapeutic monitoring in nanomedicine.