Enhancing differentiation between unipolar and bipolar depression through integration of machine learning and...

To enhance the differentiation between unipolar depression (UPD) and bipolar depression (BPD), this study integrates machine learning and deep learning models with electroencephalography (EEG) data and clinical features. Utilizing Python for data preprocessing and feature extraction, we analyzed 370 patients diagnosed with either UPD or BPD. The experimental design featured 5-fold cross-validation and leave-one-out cross-validation to assess model generalization and optimize hyperparameters through grid search. Models included Support Vector Machine, Random Forest, and neural networks such as Fully Connected Neural Network(FCNN), Recurrent Neural Network, Long Short-Term Memory networks, and Transformers. Evaluation metrics highlighted FCNN's superior performance with 76 % accuracy, 80 % sensitivity, 73 % specificity, and 76 % F1-score. Results underscore the importance of EEG biomarkers, particularly beta band activity, in distinguishing between the two conditions. The study demonstrates the potential of deep learning in identifying complex mental disorder patterns and advocates for a shift towards data-driven diagnostics in mood disorders. Future research should aim to enhance model interpretability, integrate multimodal data, and develop advanced feature extraction techniques to further precision psychiatry.