Exploring the obesity-lung inflammation connection: DNAJA1 in focus
Kaiqi Ren1, Yuxiu Wang1, Jingjing Yang1
1Department of Pulmonary and Critical Care Medicine, Northern Jiangsu People's Hospital, Clinical Medical College, Yangzhou University, Yangzhou, China.
Gene
|June 12, 2025
Summary
Obesity is linked to pulmonary inflammation. This study identified Dnaja1 as a potential biomarker in natural killer and dendritic cells, offering new insights into obesity-related lung conditions.
Area of Science:
- Pulmonary Medicine
- Immunology
- Obesity Research
Background:
- The link between obesity and lung inflammation is not well understood.
- This study uses U.S. population data (NHANES, 2007-2012) to investigate this association.
- The goal is to identify potential biomarkers for obesity-related pulmonary inflammation.
Purpose of the Study:
- To explore the relationship between obesity and pulmonary inflammation.
- To identify specific genes associated with this inflammation.
- To validate potential biomarkers using various datasets and models.
Main Methods:
- Cohort analysis of NHANES data (n=6,644).
- Differential gene expression analysis on mouse lung tissue datasets (GSE16377, GSE38093).
- Validation using single-cell RNA sequencing data (GSE216695) and mouse models.
Main Results:
- Confirmed a significant association between obesity and pulmonary inflammation.
- Identified five key genes: Dnaja1, Hspd1, Hspa1a, Hsph1, and Stip1.
- Dnaja1 expression varied in NK and cDC cells; elevated in obese mice, normalizing with weight loss.
Conclusions:
- Synthesized cohort, single-cell, and animal model data to clarify the obesity-pulmonary inflammation link.
- Identified Dnaja1 as a potential biomarker for pulmonary inflammation in obesity.
- Highlighted Dnaja1's association with NK and DC cells.
More Related Videos
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
400
08:34Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
Published on: June 3, 2016
15.0K
Related Concept Videos
01:24Obesity
411
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
411
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.7K
01:20COPD: Pathogenesis and Clinical Features
244
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
244
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
01:22Chronic Obstructive Pulmonary Disease
1.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.2K
01:26Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K