Proteostasis in cellular dormancy: lessons from yeast to oocytes.
Stephanie Rosswag de Souza1, Elvan Böke2, Gabriele Zaffagnini3
1Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Dr Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain.
Trends in Biochemical Sciences
|June 12, 2025
Summary
Cellular dormancy involves reversible cell cycle arrest to survive harsh conditions. This review explores how dormant cells maintain protein homeostasis (proteostasis) across species, from yeast to stem cells and oocytes.
Area of Science:
- Cellular Biology
- Molecular Biology
- Developmental Biology
Background:
- Cellular dormancy is a state of reversible cell cycle arrest and growth cessation.
- Dormancy enables survival in adverse environments and maintains quiescent progenitor cells for tissue homeostasis.
- Protein homeostasis (proteostasis) is crucial for intracellular integrity, especially in long-lived, non-dividing cells.
Purpose of the Study:
- To review adaptations supporting proteostasis in dormant cells.
- To identify common themes of cellular dormancy across diverse organisms.
- To highlight vertebrate oocytes as a model for studying proteostasis during dormancy.
Main Methods:
- Comparative review of existing literature on cellular dormancy.
- Analysis of proteostasis mechanisms in yeast, adult stem cells, and vertebrate oocytes.
- Identification of conserved and unique strategies for maintaining cellular function during quiescence.
Main Results:
- Dormant cells employ specific adaptations to maintain protein homeostasis.
- Common themes in cellular dormancy and proteostasis are observed across yeast, stem cells, and oocytes.
- Vertebrate oocytes present a valuable model for studying dormancy-associated proteostasis.
Conclusions:
- Sustaining proteostasis is essential for cellular viability and function during prolonged dormancy.
- Understanding these strategies offers insights into aging and tissue regeneration.
- Cross-species comparisons reveal fundamental principles of cellular resilience.
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