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Reference values for liver stiffness in children using shear-wave elastography.

Célia Charlier1, Saskia Vande Perre1, Béatrice Dubern2

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Summary

This study establishes reference liver elasticity values for healthy children using ultrasound shear wave elastography (SWE). Values decrease with age and vary by ultrasound probe, providing essential clinical data.

Keywords:
AgeChildrenLiver stiffnessShear wave elastographyTransducerUltrasound

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Area of Science:

  • Pediatric gastroenterology and hepatology
  • Medical imaging and diagnostics
  • Non-invasive liver disease assessment

Background:

  • Ultrasound shear wave elastography (SWE) is a non-invasive method for assessing liver stiffness in chronic liver diseases.
  • Establishing age-specific reference values for liver elasticity in healthy children is crucial for clinical practice.

Purpose of the Study:

  • To determine reference values for liver elasticity in a pediatric population using 2D SWE, stratified by age.
  • To provide age-based normative data for liver elasticity in children and adolescents.

Main Methods:

  • Retrospective analysis of 266 healthy children (0-19 years) undergoing abdominal ultrasonography.
  • Measurement of liver elasticity and shear wave speed using convex (6C1) and linear (SL15-4) transducers on a Canon Aplio 500 system.
  • Stratification of participants into five age groups to analyze age-dependent variations.

Main Results:

  • Overall median liver elasticity was 5.50 kPa (IQR 4.9-6.3).
  • Liver elasticity and speed decreased significantly with increasing age (p < 10⁻³).
  • Elasticity values differed between the convex (5.20 kPa) and linear (6.2 kPa) transducers (p < 10⁻⁴).

Conclusions:

  • This study provides crucial age-stratified reference values for liver elasticity in healthy children using 2D SWE.
  • The findings highlight the influence of the ultrasound probe on measured liver elasticity values.
  • These reference ranges aid in the accurate interpretation of liver stiffness measurements in pediatric patients.