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The Effect of Arteriovenous Fistula Creation on GFR Decline

Beyza Doğan1, Fatih Ergül1, Mikail Dağ1

  • 1Department of Nephrology, University of Health Sciences Konya City Hospital, Turkey.

Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
|June 12, 2025
PubMed

Insights

Arteriovenous fistula (AVF) creation in chronic kidney disease (CKD) patients significantly slows estimated glomerular filtration rate (eGFR) decline. This stabilization suggests improved adherence to treatment and diet following AVF placement in end-stage kidney disease (ESKD) patients.

Area of Science:

  • Nephrology
  • Vascular Surgery

Background:

  • Chronic kidney disease (CKD) is a major public health concern impacting patient quality of life.
  • Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines suggest discussing renal replacement therapy for CKD stage 4.
  • Arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis.

Purpose of the Study:

  • To assess changes in kidney function post-arteriovenous fistula (AVF) creation in end-stage kidney disease (ESKD) patients.
  • To evaluate the impact of AVF on the progression of kidney disease.

Main Methods:

  • Retrospective analysis of 17 CKD patients undergoing AVF creation.
  • Review of laboratory and medical records from 6 months pre- to 6 months post-AVF creation.
  • Monitoring of estimated glomerular filtration rate (eGFR) at 1, 3, and 6 months post-AVF.

Main Results:

  • The study cohort had a mean age of 62.4 years, with common comorbidities including diabetes (58.8%) and hypertension (29.4%).
  • A significant decline in eGFR was observed before AVF placement.
  • Kidney function, measured by eGFR, stabilized in the 6 months following AVF creation.

Conclusions:

  • AVF creation in CKD patients significantly reduces the rate of eGFR decline.
  • This stabilization may result from increased patient awareness and improved adherence to dietary and treatment regimens.
  • AVF placement appears to positively influence kidney function trajectory in ESKD patients.
Abstract

Keywords:
arteriovenous fistulachronic kidney diseaseglomerular filtration ratehemodialysis

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