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Updated: Jun 14, 2025

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
Divergent Synthesis of Symmetric Benzenes and Fluorenones
Yingjian Gong1, Li Li1, Qian Wu1
1School of Chemistry and Chemical Engineering, Chongqing University, 174 Shazheng Street, Chongqing 400044, China.
Abstract:
The benzene ring is a prevalent core structure in both biologically significant compounds and functional materials. This prompts the development of innovative methods for synthesizing benzene derivatives. We present a divergent synthetic strategy for accessing 1,2-difuryl-substituted symmetrical benzene and highly functionalized fluorenones. In this approach, all aromatic cores are generated through a copper-mediated dimeric cycloaromatization cascade sequence, utilizing readily available dienynyl ketones. This protocol not only offers an alternative method for synthesizing symmetrical aromatics but also provides a framework for the oxidative transformation of furans into synthetically valuable substances.
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