Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nonconscious Mimicry01:13

Nonconscious Mimicry

3.6K
Nonconscious mimicry occurs when individuals alter their mannerisms to match the behaviors and expressions of those nearby, without intention.
3.6K
Perception of Sound Waves01:01

Perception of Sound Waves

4.7K
The human ear is not equally sensitive to all frequencies in the audible range. It may perceive sound waves with the same pressure but different frequencies as having different loudness. Moreover, the perception of sound waves depends on the health of an individual's ears, which decays with age. The health of one's ears may also be affected by regular exposure to loud noises.
The pitch of a sound depends on the frequency and the pressure amplitude of the source. Two sounds of the same...
4.7K
Brain Waves01:23

Brain Waves

4.2K
Brain waves are electrical signals generated by the neurons in the brain, which are regularly monitored to measure mental activities. Brain waves and their frequency ranges can be measured using an electroencephalogram or EEG. There are four main types of brain waves, each with distinct characteristics:
4.2K
Higher Mental Functions of the Brain: Language01:10

Higher Mental Functions of the Brain: Language

6.0K
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
6.0K
Neurons as Communicators of the Brain01:22

Neurons as Communicators of the Brain

5.2K
Neurons, the fundamental units of the brain and nervous system, function as the primary transmitters of information throughout the body. Their ability to communicate through electrical and chemical signals is vital for every bodily function, from regulating the heartbeat to processing complex thoughts. Each neuron has three main components: the cell body (soma), dendrites, and an axon, each specialized to facilitate swift and efficient neural communication.
Cell Body
The cell body, also known...
5.2K
Sleepwalking and Sleep Talking01:17

Sleepwalking and Sleep Talking

1.8K
Somnambulism, commonly known as sleepwalking, involves individuals engaging in activities ranging from simple walking to more complex behaviors such as driving. Sleepwalking typically occurs during the slow-wave sleep stages 3 and 4 early in the night when the person is not dreaming, contradicting the myth that sleepwalkers are acting out their dreams.
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A mosaic of whole-body representations on the human precentral gyrus.

Nature·2026
Same author

Stereotactic electroencephalogram lead placement in patient with hemophilia B: illustrative case.

Journal of neurosurgery. Case lessons·2026
Same author

Long-term independent use of an intracortical brain-computer interface for speech and cursor control.

Nature medicine·2026
Same author

Neural decoding of speech using deep neural ensembles.

bioRxiv : the preprint server for biology·2026
Same author

Neural activation is enhanced with operational task ecological validity during complex cognitive tasks.

Frontiers in human neuroscience·2026
Same author

Observation-Related Activity in Human Motor Cortex Increases with Effector Anthropomorphicity.

bioRxiv : the preprint server for biology·2026
Same journal

Daily briefing: How cooperation built the world.

Nature·2026
Same journal

Deep-sea oddities and boatloads of other new species - June's best science images.

Nature·2026
Same journal

From cloning to gene-editing: the enduring legacy of Dolly the sheep.

Nature·2026
Same journal

Time to give hydration breaks the red card? What science says about keeping cool.

Nature·2026
Same journal

Universities are relying on AI-detection software to catch cheating. How well do the programs work?

Nature·2026
Same journal

Daily briefing: 'Cyborg' cockroaches breathe underwater with printed suit.

Nature·2026
See all related articles

Related Experiment Video

Updated: May 2, 2026

Surgical Implantation of Chronic Neural Electrodes for Recording Single Unit Activity and Electrocorticographic Signals
08:26

Surgical Implantation of Chronic Neural Electrodes for Recording Single Unit Activity and Electrocorticographic Signals

Published on: February 24, 2012

47.4K

An instantaneous voice-synthesis neuroprosthesis.

Maitreyee Wairagkar1, Nicholas S Card2, Tyler Singer-Clark2,3

  • 1Department of Neurological Surgery, University of California, Davis, Davis, CA, USA. mwairagkar@ucdavis.edu.

Nature
|June 12, 2025
PubMed
Summary
This summary is machine-generated.

This study presents a novel brain-to-voice neuroprosthesis that synthesizes natural-sounding speech directly from brain activity. This brain-computer interface (BCI) restores expressive communication for individuals with paralysis, including intonation and melody.

More Related Videos

An Implantable System For Chronic In Vivo Electromyography
09:52

An Implantable System For Chronic In Vivo Electromyography

Published on: April 21, 2020

10.6K
Author Spotlight: Investigating the Impact of Emotional Prosodies on Voice Recognition and Perception
05:48

Author Spotlight: Investigating the Impact of Emotional Prosodies on Voice Recognition and Perception

Published on: August 9, 2024

1.4K

Related Experiment Videos

Last Updated: May 2, 2026

Surgical Implantation of Chronic Neural Electrodes for Recording Single Unit Activity and Electrocorticographic Signals
08:26

Surgical Implantation of Chronic Neural Electrodes for Recording Single Unit Activity and Electrocorticographic Signals

Published on: February 24, 2012

47.4K
An Implantable System For Chronic In Vivo Electromyography
09:52

An Implantable System For Chronic In Vivo Electromyography

Published on: April 21, 2020

10.6K
Author Spotlight: Investigating the Impact of Emotional Prosodies on Voice Recognition and Perception
05:48

Author Spotlight: Investigating the Impact of Emotional Prosodies on Voice Recognition and Perception

Published on: August 9, 2024

1.4K

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Speech Synthesis

Background:

  • Brain-computer interfaces (BCIs) offer potential for communication restoration in neurological conditions.
  • Existing BCIs primarily translate neural activity into text, lacking speech's nuances like prosody.
  • Restoring natural, expressive voice is crucial for effective communication.

Purpose of the Study:

  • To develop and demonstrate a brain-to-voice neuroprosthesis for synthesizing intelligible and expressive speech.
  • To decode neural activity for real-time voice synthesis with closed-loop audio feedback.
  • To enable individuals with severe speech loss to communicate using their own synthesized voice.

Main Methods:

  • Implanted 256 microelectrodes into the ventral precentral gyrus of a participant with amyotrophic lateral sclerosis (ALS).
  • Developed a neural decoder to translate intracortical activity into speech signals, overcoming the lack of ground-truth speech data.
  • Enabled real-time voice synthesis with closed-loop audio feedback, allowing for modulation of prosody and melody.

Main Results:

  • Accurately synthesized the participant's voice from neural activity, including phonemic content.
  • Successfully decoded and synthesized paralinguistic features, enabling real-time modulation of intonation.
  • Participant could sing short melodies using the BCI-synthesized voice.

Conclusions:

  • Demonstrated the feasibility of a brain-to-voice neuroprosthesis for restoring expressive speech in individuals with paralysis.
  • This technology has the potential to significantly improve communication abilities and quality of life for those with severe dysarthria.
  • Further research can advance BCI technology for more nuanced and natural voice restoration.