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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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  1. Home
  3. Lower Limb Bone Mineral Density Reduction Is Closely Relative With Diabetic Peripheral Neuropathy In The Postmenopausal Women And Men Over 50 Years Old With T2dm: A Cross-sectional, Controlled Study.
  1. Home
  3. Lower Limb Bone Mineral Density Reduction Is Closely Relative With Diabetic Peripheral Neuropathy In The Postmenopausal Women And Men Over 50 Years Old With T2dm: A Cross-sectional, Controlled Study.

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Lower Limb Bone Mineral Density Reduction is Closely Relative With Diabetic Peripheral Neuropathy in the

Xiaopu Lin1, Xiaoming Wen2,3, Yanting Zhou2,3

  • 1Department of Huiqiao Medical Centre, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Calcified Tissue International
|June 12, 2025

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
Bone mineral densityDiabetic peripheral neuropathyOsteoporosis siteType 2 diabetes mellitus (T2DM)

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Lower bone density is linked to diabetic peripheral neuropathy (DPN) in type 2 diabetes patients over 50. Reduced bone mineral density (BMD) in the femoral neck and hip correlates with nerve damage, indicating a potential risk factor for DPN.

Area of Science:

  • Endocrinology
  • Neurology
  • Orthopedics

Background:

  • Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes mellitus (T2DM).
  • Osteoporosis and reduced bone mineral density (BMD) are prevalent in aging populations, but their association with DPN requires further investigation.

Purpose of the Study:

  • To investigate the relationship between BMD at various skeletal sites and the presence of DPN in patients with T2DM.
  • To identify potential predictors of DPN based on BMD measurements and disease duration.

Main Methods:

  • A cross-sectional, controlled study involving T2DM patients.
  • Measurement of nerve conduction parameters and BMD at different sites.
  • Statistical analyses including Pearson's correlation and Receiver Operating Characteristic (ROC) analysis.

Main Results:

  • The prevalence of osteoporosis was significantly higher in the DPN group compared to the non-DPN group.
  • Lower Z/T scores for femoral neck and hip joint BMD were observed in patients with DPN.
  • Reduced sensory nerve amplitude and conduction velocity correlated positively with femoral neck and hip joint BMD T-scores in older T2DM patients.

Conclusions:

  • Reduced lower limb BMD is significantly associated with DPN in postmenopausal women and men over 50 with T2DM.
  • BMD measurements, particularly at the femoral neck and hip, may serve as potential indicators for DPN risk assessment in conjunction with T2DM duration.