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Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

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Correlation analysis between serum Klotho and cognitive function in diabetes individuals.

Li Gong¹, Qing Ge²

¹Department of Neurology and Endocrinology, Chongqing Jiulongpo People's Hospital, No. 23, Yangjiaping Qianjin Road, Jiulongpo District, Chongqing, 400050, China.

Diabetology & Metabolic Syndrome

|June 12, 2025

Summary

This summary is machine-generated.

Higher serum Klotho levels correlate with better cognitive function in individuals with diabetes, especially in females. This study highlights sex differences in the Klotho-cognition relationship within this population.

Keywords:

Cognitive function Diabetes NHANES Restricted cubic spline Serum Klotho

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Area of Science:

Endocrinology
Neuroscience
Gerontology

Background:

Klotho, blood glucose, and cognition are linked, but data on Klotho's role in diabetic cognitive function is scarce.
Understanding Klotho's impact on cognition in diabetes is crucial for potential therapeutic strategies.

Purpose of the Study:

To investigate the association between serum Klotho levels and cognitive function in individuals with diabetes.
To explore potential sex differences in this relationship.

Main Methods:

Utilized National Health and Nutrition Examination Survey (NHANES) data (2011-2014).
Employed generalized linear regression and restricted cubic spline (RCS) analysis.
Conducted sex-stratified analyses to examine correlations.

Main Results:

Serum Klotho levels positively correlated with DSST and overall cognitive scores in individuals with diabetes.
An inverted U-shaped relationship between Klotho and DSST scores was observed in females, with a turning point at Ln(Klotho) of 6.766 pg/mL.
Significant correlations were particularly noted in females, suggesting sex-specific effects.

Conclusions:

Elevated serum Klotho levels are associated with enhanced cognitive function in individuals with diabetes.
The study provides novel evidence for sex differences in the Klotho-cognition association among diabetic individuals.
Findings underscore the importance of considering sex in understanding Klotho's role in diabetic cognitive health.