Related Experiment Video

Updated: Jun 16, 2025

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
10:46

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data

Published on: December 9, 2015

10.7K

Is There a Relationship Between Vitamin D Deficiency and Primary Monosymptomatic Enuresis Nocturna?

Abdulgani Gülyüz1

  • 1Department of Pediatrics, School of Medicine, Turgut Ozal University, 06560 Malatya, Turkey.

Diagnostics (Basel, Switzerland)
|June 13, 2025
PubMed

Insights

Children with primary monosymptomatic enuresis nocturna (PMNE) have significantly lower vitamin D levels. Vitamin D deficiency is a key factor associated with childhood bedwetting, suggesting routine testing and supplementation may be beneficial.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Nutritional Science

Background:

  • Primary monosymptomatic enuresis nocturna (PMNE) is a common pediatric condition.
  • The role of vitamin D in PMNE is not fully understood.
  • Vitamin D deficiency is prevalent globally, particularly in children.

Purpose of the Study:

  • To investigate the association between vitamin D deficiency and PMNE in children.
  • To identify risk factors for PMNE.
  • To explore the correlation between vitamin D levels and enuresis frequency.

Main Methods:

  • Retrospective case-control study involving 307 PMNE patients and 254 healthy controls (aged 5-18).
  • Serum 25(OH)D3 levels measured via chemiluminescence immunoassay.
  • Statistical analyses included Mann-Whitney U, Chi-square, Pearson correlation, and logistic regression.

Main Results:

  • PMNE patients exhibited significantly lower serum 25(OH)D3 levels compared to controls (p < 0.001).
  • Vitamin D deficiency was more common in the PMNE group.
  • Vitamin D deficiency (OR: 3.164) and family history of enuresis (OR: 2.790) were independent risk factors for PMNE.
  • A significant negative correlation was observed between vitamin D levels and weekly bedwetting frequency (r = -0.377, p < 0.001).

Conclusions:

  • Children with PMNE demonstrate significantly lower serum 25(OH)D3 levels.
  • Vitamin D deficiency is an independent associated factor for PMNE.
  • Routine vitamin D level evaluation and investigation into supplementation benefits for children with PMNE are recommended.

Keywords:
associated factorsbedwettingchildprimary monosymptomatic enuresis nocturnavitamin D deficiency

More Related Videos

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling03:46

Chronic Sleep Deprivation in Mouse Pups by Means of Gentle Handling

Published on: October 11, 2018

10.0K
Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis07:45

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

Published on: February 9, 2021

3.6K

Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.1K
Regulation of Water Intake01:25

Regulation of Water Intake

Osmolality refers to the number of solute particles per kilogram of solvent in a solution. Plasma osmolality specifically indicates the total number of solute particles per kilogram of water in blood plasma. This value reflects the body's hydration status and is tightly regulated through mechanisms controlling water intake and output. While water consumption is a conscious decision, the body has intrinsic regulatory systems to maintain fluid balance. Dehydration, a state of water deficit...
486
Restless Leg Syndrome and Night Terrors01:27

Restless Leg Syndrome and Night Terrors

Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
159
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
138
The Micturition Reflex01:26

The Micturition Reflex

Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
516
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
163