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Related Experiment Video

Updated: Jun 16, 2025

Author Spotlight: Unveiling the Role of TMOD3 in Platinum Resistance and Immune Infiltration in Ovarian Cancer

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Prognostic Significance of RBM3 Expression in Epithelial Ovarian Cancer: A Tissue Microarray-Based Study.

Hyeong Chan Shin¹, Hye Won Lee¹, So-Jin Shin²

¹Department of Pathology, Keimyung University School of Medicine, Daegu 42601, Republic of Korea.

Diagnostics (Basel, Switzerland)

|June 13, 2025

Summary

This summary is machine-generated.

RNA-binding motif protein 3 (RBM3) expression correlates with better outcomes in epithelial ovarian cancer (OC). While not an independent marker, RBM3 aids in risk stratification for OC patients.

Keywords:

RBM3 biomarker immunohistochemistry ovarian cancer prognosis survival analysis

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Area of Science:

Oncology
Molecular Biology
Pathology

Background:

RNA-binding motif protein 3 (RBM3) is a cold-shock protein linked to favorable prognoses in several cancers.
The prognostic role of RBM3 in epithelial ovarian cancer (OC) requires further investigation.

Purpose of the Study:

To assess the prognostic significance of RBM3 expression in epithelial ovarian cancer (OC).
To investigate the association between RBM3 expression and clinicopathological features in OC.

Main Methods:

Retrospective analysis of 183 epithelial ovarian cancer (OC) cases.
Immunohistochemistry used to evaluate RBM3 expression via a nuclear score (NS).
Statistical analyses included chi-square tests, Kaplan-Meier curves, and Cox regression models.

Main Results:

High RBM3 expression (NS > 1) found in 51.4% of OC cases.
High RBM3 expression associated with favorable histologic subtypes, early FIGO stage, and no distant metastasis.
RBM3 expression correlated with improved disease-free and overall survival, but lacked independent prognostic significance in multivariate analysis.

Conclusions:

RBM3 expression is linked to favorable pathological features in epithelial ovarian cancer.
RBM3 may serve as a complementary biomarker for risk stratification and prognosis in OC, despite not being an independent prognostic marker.