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  11. Using The Rise And Fall Of Oxidative Stress And Inflammation Post-exercise To Evaluate The Effect Of Methylsulfonylmethane Supplementation On Immune Response Mrna.
  1. Home
  3. Research Domains
  5. Health Sciences
  7. Sports Science And Exercise
  9. Biomechanics
  11. Using The Rise And Fall Of Oxidative Stress And Inflammation Post-exercise To Evaluate The Effect Of Methylsulfonylmethane Supplementation On Immune Response Mrna.

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Using the Rise and Fall of Oxidative Stress and Inflammation Post-Exercise to Evaluate the Effect of Methylsulfonylmethane Supplementation on Immune Response mRNA.

Brian K McFarlin1,2, John H Curtis1, Heidi N du Preez3

  • 1Applied Physiology Laboratory, University of North Texas, Denton, TX 76205, USA.

Nutrients
|June 13, 2025

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
MSMimmune cell activationmuscle fatiguemuscle injury

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Methylsulfonylmethane (MSM) supplementation may enhance post-exercise recovery by modulating immune responses and reducing oxidative stress in runners. This study shows lower MSM doses effectively impact immune-related mRNA expression after endurance running.

Area of Science:

  • Exercise Physiology
  • Immunology
  • Nutritional Biochemistry

Background:

  • Long-duration aerobic exercise induces transient oxidative stress and inflammation, serving as a model for evaluating nutritional supplements.
  • Nutritional interventions can potentially modulate the physiological responses to strenuous exercise.

Purpose of the Study:

  • To investigate the effects of Methylsulfonylmethane (MSM) supplementation on immune response-related mRNA expression following endurance exercise.
  • To assess if lower doses of MSM can influence post-exercise immune markers.

Main Methods:

  • Healthy, experienced runners were assigned to either an MSM (1.0 g/d) or placebo group for 30 days prior to a 21.1 km run.
  • Blood samples were collected pre-exercise, and 2 and 4 hours post-exercise.
  • Expression of approximately 700 immune response-associated mRNAs was analyzed.

    • Main Results:

    • This study demonstrated significant effects of MSM at lower doses (0.5-1.0 g/d) compared to previous higher-dose studies.
    • MSM supplementation altered the expression of 29 mRNAs across four key immune pathways: inflammatory response, myeloid cell invasion, NK cell activity, and notch signaling.
    • These changes were observed at 2 hours and/or 4 hours post-exercise.

    Conclusions:

    • MSM supplementation may support muscle recovery by enhancing macrophage response and accelerating tissue repair after exercise.
    • MSM appears to bolster innate immune responsiveness and improve resistance to exercise-induced oxidative stress.
    • Further research is warranted to explore MSM's potential in managing chronic inflammatory conditions.