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Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Overview of Carbohydrate Metabolism01:19

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Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
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Carbohydrate Metabolism01:36

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Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
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Psychoneuroimmunology: Diabetes and Cancer01:19

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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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  1. Home
  3. Research Domains
  5. Language, Communication And Culture
  7. Cultural Studies
  9. Consumption And Everyday Life
  11. Cultural And Molecular Factors Predisposed To Non-alcoholic Fatty Liver Disease And Type 2 Diabetes Mellitus.
  1. Home
  3. Research Domains
  5. Language, Communication And Culture
  7. Cultural Studies
  9. Consumption And Everyday Life
  11. Cultural And Molecular Factors Predisposed To Non-alcoholic Fatty Liver Disease And Type 2 Diabetes Mellitus.

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Cultural and Molecular Factors Predisposed to Non-Alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus.

Hanna George1, Fajar Shodiq Permata1,2, Crystal M D'Souza1

  • 1Department of Anatomy, College of Medicine & Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.

Nutrients
|June 13, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Cultural factors and molecular mechanisms drive the global rise in non-alcoholic fatty liver disease (NAFLD). Understanding these elements is key to improving patient care and treatment adherence for this complex condition.

Keywords:
NAFLDautophagyculturediabetes mellitus

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Area of Science:

  • Hepatology
  • Public Health
  • Medical Sociology

Background:

  • Non-alcoholic fatty liver disease (NAFLD) shows a rapid global increase in prevalence.
  • NAFLD significantly impacts public health, necessitating a comprehensive understanding of its drivers.

Purpose of the Study:

  • To review the influence of cultural factors and molecular mechanisms on NAFLD progression.
  • To highlight the importance of cultural competence in managing NAFLD.

Main Methods:

  • Literature search of major research databases (PubMed, Scopus, ADA, ALF, Diabetes UK).
  • Analysis of cultural norms, molecular pathways, and comorbidities associated with NAFLD.

Main Results:

  • Cultural norms impact health perceptions, healthcare decisions, and treatment adherence.
dietary patterns
epidemiology
ethnicity
genetic pre-disposition
insulin resistance
oxidative stress
  • Molecular pathways include lipid metabolism, insulin resistance, oxidative stress, gut microbiome alterations, and inflammation.
  • NAFLD progression is multifactorial, influenced by both cultural and biological elements.

    • Conclusions:

    • The global rise in NAFLD is attributed to a synergy of cultural preferences and molecular factors.
    • Effective NAFLD management requires integrating cultural understanding with molecular insights.
    • Increased NAFLD prevalence correlates with higher rates of comorbidities like cardiovascular disease and diabetes.