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  11. Vitamin D Status Determines The Effect Of Cabergoline On Sexual Function And Depressive Symptoms In Hyperprolactinemic Women

Vitamin D Status Determines the Effect of Cabergoline on Sexual Function and Depressive Symptoms in Hyperprolactinemic Women

Robert Krysiak1, Karolina Kowalcze2,3, Johannes Ott4

  • 1Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medyków 18, 40-752 Katowice, Poland.

Nutrients
|June 13, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

Vitamin D levels impact cabergoline effectiveness for women with prolactin excess. Sufficient vitamin D enhances improvements in sexual function and mood, while deficiency lessens these benefits.

Area of Science:

  • Endocrinology
  • Reproductive Health
  • Nutritional Science

Background:

  • Hyperprolactinemia is linked to female sexual dysfunction.
  • Dopamine agonists like cabergoline improve sexual function.
  • Vitamin D deficiency may reduce cabergoline's extra-sexual benefits.

Purpose of the Study:

  • To investigate if vitamin D status influences cabergoline's effects on sexual function and depression in women with prolactin excess.
  • To compare outcomes based on vitamin D levels (deficiency, insufficiency, sufficiency).

Main Methods:

  • Prospective cohort study of 75 women with prolactin excess.
  • Group assignment based on vitamin D status (deficiency, insufficiency, sufficiency).
  • Six months of cabergoline treatment with pre- and post-treatment assessments of sexual function (FSFI) and depressive symptoms (BDI-II).
Keywords:
moodprolactin excessreproductive axissexual dysfunction

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Main Results:

  • Cabergoline improved sexual function (FSFI scores) and reduced depressive symptoms (BDI-II scores) in all groups, but effects were strongest in vitamin D-sufficient women.
  • Improvements correlated with decreased prolactin and vitamin D levels, increased testosterone and estradiol, and reduced depressive symptoms.
  • Vitamin D deficiency attenuated the positive effects of cabergoline.

Conclusions:

  • Low vitamin D status diminishes the beneficial impact of cabergoline on sexual function and mood in reproductive-age women.
  • Vitamin D status is a critical factor to consider when treating hyperprolactinemia with cabergoline.
vitamin D homeostasis
women’s health