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  3. Advances In Isorhamnetin Treatment Of Malignant Tumors: Mechanisms And Applications.
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  3. Advances In Isorhamnetin Treatment Of Malignant Tumors: Mechanisms And Applications.

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Advances in Isorhamnetin Treatment of Malignant Tumors: Mechanisms and Applications.

Chen Mei1, Ying Liu1, Xueze Lyu2,3

  • 1Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China.

Nutrients
|June 13, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Isorhamnetin (ISO), a natural flavonoid, shows promise in fighting cancer by regulating cell cycles and immune responses. Further research is needed to optimize its use in clinical settings.

Keywords:
antitumor mechanismclinical applicationisorhamnetinmalignant tumornatural medicine

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Area of Science:

  • Natural Products Chemistry
  • Pharmacology
  • Oncology

Background:

  • Isorhamnetin (ISO) is a naturally occurring flavonoid with demonstrated multitargeted antitumor properties.
  • Recent research highlights ISO's potential in cancer treatment due to its diverse molecular mechanisms.

Purpose of the Study:

  • To systematically review the molecular mechanisms by which ISO inhibits malignant tumors.
  • To explore ISO's synergistic effects with existing cancer therapies and its clinical translation potential.
  • To evaluate ISO's role in modulating the tumor microenvironment and enhancing antitumor immunity.

Main Methods:

  • Systematic review of experimental studies on Isorhamnetin's antitumor effects.
  • Analysis of molecular pathways regulated by ISO, including cell cycle, PI3K/AKT/mTOR, MAPK, and apoptosis/autophagy.
  • Review of pharmacokinetic studies and novel delivery systems for ISO.

    • Main Results:

    • ISO inhibits tumor proliferation via cell cycle arrest, apoptosis, and endoplasmic reticulum stress.
    • ISO enhances antitumor immunity by modulating the immune microenvironment.
    • Novel delivery systems like nano-formulations improve ISO bioavailability and efficacy.
    • ISO demonstrates potential in reducing chemotherapy-induced nephrotoxicity and overcoming tumor resistance.

    Conclusions:

    • Isorhamnetin exhibits significant potential as an anticancer agent through multiple molecular pathways.
    • Further preclinical and clinical studies are required to establish optimal dosing and validate its efficacy across species.
    • ISO holds promise for developing novel cancer therapeutics and enhancing existing treatments.