Related Experiment Video
Updated: Jun 16, 2025

Murine Fecal Isolation and Microbiota Transplantation
Published on: May 26, 2023
In Search of Healthy Ageing: A Microbiome-Based Precision Nutrition Approach for Type 2 Diabetes Prevention
Adriana González1, Asier Fullaondo1, Adrian Odriozola1
1Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU), 48940 Bilbao, Spain.
Precision nutrition using food recommendations can optimize gut microbiota to prevent type 2 diabetes (T2D). This study identified key bacteria and addressed challenges for healthy aging strategies.
Area of Science:
- Microbiome research
- Nutritional science
- Gerontology
Background:
- Type 2 diabetes (T2D) poses a significant global health burden, especially for the elderly.
- Nutritional interventions and gut microbiota modulation are crucial for T2D prevention.
- Precision nutrition targeting the gut microbiota may offer a novel strategy for T2D prevention.
Purpose of the Study:
- To identify a gut microbiota profile associated with T2D prevention.
- To develop precision nutrition tools for optimizing this profile.
- To analyze the impact of overweight on microbiota and intervention response.
- To address challenges in implementing microbiome-based precision nutrition for T2D prevention.
Main Methods:
- A literature review on gut microbiota and T2D prevention.
- A 3-month precision nutrition intervention in 13 healthy Spanish older adults (normal weight and overweight) using the Phymofood system.
- Analysis of fecal microbiota composition pre- and post-intervention via 16S rRNA gene sequencing.
Main Results:
- Identified 31 bacteria potentially protective against T2D.
- Observed increased abundance of beneficial genera (e.g., *Butyrivibrio*, *Faecalibacterium*) and species (e.g., *Eshraghiella crossota*, *Faecalibacterium prausnitzii*).
- Found that overweight status influences microbiota composition and response to precision nutrition.
Conclusions:
- A specific gut microbiota profile linked to T2D prevention was identified.
- Precision nutrition interventions can enhance beneficial gut bacteria.
- Overweight is a critical factor to consider in microbiome-based precision nutrition for T2D prevention and healthy aging.
More Related Videos
11:44Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
Published on: January 19, 2022
07:15An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
Related Concept Videos
Diabetes Mellitus: Type 2 and Gestational
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Cancer Prevention
Some...
Oral Hypoglycemic Agents: Biguanides and Glitazones