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  11. Nutrient-driven Antioxidant Interventions For Prevention Of Age-related And Diabetic Cataracts

Nutrient-Driven Antioxidant Interventions for Prevention of Age-Related and Diabetic Cataracts

Rosa Giglio1, Serena Milan1, Leandro Inferrera1

  • 1Department of Medicine, Surgery and Health Sciences, University of Trieste, 34127 Trieste, Italy.

Nutrients
|June 13, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

Nutritional antioxidants show promise in preventing age-related and diabetic cataracts by reducing oxidative damage. Further research and advanced delivery methods are key to their clinical use.

Area of Science:

  • Ophthalmology
  • Nutritional Science
  • Nanomedicine

Background:

  • Cataract formation is a leading cause of visual impairment globally.
  • Antioxidant interventions are being explored as non-surgical strategies for cataract prevention.
  • Age-related and diabetic cataracts are significant public health concerns.

Purpose of the Study:

  • To review preclinical evidence on nutritional antioxidants for preventing age-related and diabetic cataracts.
  • To summarize findings on specific antioxidant agents and their mechanisms.
  • To discuss advances in drug delivery for ocular applications.

Main Methods:

  • Review of recent preclinical studies on nutritional antioxidants.
  • Analysis of agents including trimetazidine, Moringa oleifera, ginsenoside Rg1, lanosterol nanoparticles, β-casomorphin-7, and cerium oxide nanotherapies.
Keywords:
antioxidantscataract preventionlens transparencyoxidative stress

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  • Examination of novel drug delivery systems for lens penetration.

    • Main Results:

    • Several nutritional antioxidants demonstrate efficacy in mitigating oxidative damage and preserving lens clarity.
    • Modulation of redox signaling pathways is a key mechanism of action.
    • Advanced delivery systems show potential for overcoming ocular barriers.

    Conclusions:

    • Nutritional antioxidants hold therapeutic potential for preventing age-related and diabetic cataracts.
    • Translational research is needed to optimize clinical application.
    • Drug delivery innovations are crucial for effective antioxidant therapy in the avascular lens.