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Analgesia and Pain Management01:25

Analgesia and Pain Management

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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  1. Home
  3. An Isobolographic Analysis Of The Antinociceptive Effect Of Salvia Hispanica L. In Combination With Citrus × Latifolia In Rats.
  1. Home
  3. An Isobolographic Analysis Of The Antinociceptive Effect Of Salvia Hispanica L. In Combination With Citrus × Latifolia In Rats.

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An Isobolographic Analysis of the Antinociceptive Effect of Salvia hispanica L. in Combination with Citrus ×

Lilian Dolores Chel-Guerrero1, Rolffy Ortiz-Andrade1, Enrique Sauri-Duch2

  • 1Laboratorio de Farmacología, Facultad de Química, Universidad Autónoma de Yucatán, Mérida 97000, Mexico.

Nutrients
|June 13, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Salvia hispanica seeds and Lime juice show synergistic pain relief in rats. Their combination offers a promising, non-toxic approach for managing inflammatory and visceral pain.

Keywords:
Citrus × latifoliaSalvia hispanicaantinociceptionantioxidant activityherb–drug interactioninflammatory painmedicinal plantssynergismtraditional medicine

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Area of Science:

  • Pharmacology and Toxicology
  • Natural Product Research
  • Pain Management

Background:

  • Herbal medicine is increasingly explored for pain relief.
  • Salvia hispanica (chia) and Citrus × latifolia (lime) possess known medicinal properties.
  • Understanding synergistic interactions of natural compounds is crucial for therapeutic development.

Purpose of the Study:

  • To evaluate the antinociceptive (pain-relieving) effects of Salvia hispanica seed extract and Citrus × latifolia juice.
  • To investigate the interaction between these two natural agents when combined.
  • To assess the safety profile of the individual extracts.

Main Methods:

  • Dose-response studies were conducted on rats using the acetic acid-induced writhing test.
  • n-hexane extract of S. hispanica seeds and C. × latifolia juice were administered orally.
  • Isobolographic analysis quantified the interaction between the combined treatments.

    • Main Results:

    • Both S. hispanica and C. × latifolia demonstrated dose-dependent antinociceptive effects.
    • C. × latifolia (ED50 = 43.95 mg/kg) was more potent than S. hispanica (ED50 = 112.9 mg/kg).
    • The combination exhibited significant synergistic antinociceptive activity (Zexp = 4.9 mg/kg) and was found to be non-toxic (OECD-423).

    Conclusions:

    • The combination of Salvia hispanica and Citrus × latifolia displays synergistic pain-relieving properties.
    • This synergistic effect suggests a promising therapeutic strategy for inflammatory and visceral pain.
    • The findings indicate potential clinical utility for this natural combination in pain management.