Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

27
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
27
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

2.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.3K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

520
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
520
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

2.5K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.5K
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

10.9K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.9K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

910
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
910

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Restoring the powerhouse: mitochondrial transplantation in regenerative medicine and cancer therapy.

Nanoscale·2026
Same author

Comparative risk of epilepsy with SGLT2 inhibitors versus incretin-based therapies in type 2 diabetes.

Epilepsia·2026
Same author

Finerenone Exposure and Ischemic Stroke in Patients with Type 2 Diabetes and Chronic Kidney Disease: A Propensity Score-Matched Cohort Study.

Clinical medicine (London, England)·2026
Same author

Smoking-associated modulation of gut microbiota shapes response to immune checkpoint inhibitors in non-small cell lung cancer.

Cancer immunology, immunotherapy : CII·2026
Same author

Gut microbiome signatures discriminate deep vein thrombosis through machine learning and metabolic analysis.

Scientific reports·2026
Same author

Advances in body composition imaging for diagnosis and monitoring: From radiologic assessment to precision medicine.

Journal of the Chinese Medical Association : JCMA·2026

Related Experiment Video

Updated: Jun 16, 2025

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression
04:36

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression

Published on: January 12, 2024

1.1K

Microvascular Complications and Cancer Risk in Type 2 Diabetes: A Population-Based Study.

Yu-Hsin Yen1, James Cheng-Chung Wei2,3,4, Fu-Shun Yen5

  • 1Duke-NUS Medical School, 8 College Rd., Singapore 169857, Singapore.

Cancers
|June 13, 2025
PubMed
Summary
This summary is machine-generated.

Type 2 diabetes (T2D) patients with microvascular complications like neuropathy or retinopathy do not face higher cancer risk or mortality. However, these complications significantly increase overall mortality in a dose-dependent manner.

Keywords:
cancer incidencecancer mortalitydiabetic kidney diseasediabetic neuropathydiabetic retinopathymicrovascular complicationstype 2 diabetes

More Related Videos

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations
08:21

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

1.2K
Laser Doppler: A Tool for Measuring Pancreatic Islet Microvascular Vasomotion In Vivo
10:39

Laser Doppler: A Tool for Measuring Pancreatic Islet Microvascular Vasomotion In Vivo

Published on: March 8, 2018

8.3K

Related Experiment Videos

Last Updated: Jun 16, 2025

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression
04:36

Author Spotlight: Understanding Retinal Vessel Resilience and Disease Progression

Published on: January 12, 2024

1.1K
Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations
08:21

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

1.2K
Laser Doppler: A Tool for Measuring Pancreatic Islet Microvascular Vasomotion In Vivo
10:39

Laser Doppler: A Tool for Measuring Pancreatic Islet Microvascular Vasomotion In Vivo

Published on: March 8, 2018

8.3K

Area of Science:

  • Endocrinology and Metabolism
  • Oncology
  • Epidemiology

Background:

  • Type 2 diabetes (T2D) and cancer share underlying biological pathways.
  • The impact of T2D microvascular complications on cancer risk is not well-established.

Purpose of the Study:

  • To investigate the association between microvascular complications in T2D and cancer incidence.
  • To determine if T2D patients with microvascular complications have increased cancer-related mortality.

Main Methods:

  • Nationwide cohort study using Taiwan National Health Insurance Research Database (2008-2021).
  • Inclusion of individuals newly diagnosed with T2D.
  • Multivariable Cox proportional hazards models to assess outcomes.

Main Results:

  • No significant increase in major cancer risk (oral, thyroid, breast, respiratory, digestive, lymphoid) for T2D patients with diabetic neuropathy, retinopathy, or chronic kidney disease.
  • Microvascular complications were not linked to higher cancer-specific mortality.
  • A dose-dependent increase in all-cause mortality was observed with increasing number of microvascular complications.

Conclusions:

  • Microvascular complications in T2D are not associated with elevated cancer risk or cancer-specific mortality.
  • These complications significantly increase all-cause mortality in T2D patients.
  • Provides epidemiological evidence on the distinct impacts of diabetes complications on cancer versus overall survival.