Related Experiment Video
Updated: Jun 16, 2025
05:45
Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
Published on: July 31, 2017
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Interplay Between the Epigenome, the Microenvironment, and the Immune System in Neuroblastoma
Valentina Andrade-Perez1,2, Noël J-M Raynal1,2
1Département de Pharmacologie et Physiologie, Faculté de Médecine, Université de Montréal, Montréal, QC H3T 1C5, Canada.
Cancers
|June 13, 2025
Summary
Novel treatments are emerging for high-risk neuroblastoma (NB), a challenging childhood cancer. Research focuses on targeted therapies and immunotherapy to improve survival rates and reduce side effects from current treatments.
Area of Science:
- Pediatric Oncology
- Cancer Genetics
- Immunotherapy
Background:
- Neuroblastoma (NB) is the most common extracranial childhood cancer.
- High-risk NB patients have unsatisfactory survival rates despite current treatments.
- Conventional treatments for NB cause significant side effects.
Purpose of the Study:
- To review novel treatment strategies for high-risk neuroblastoma.
- To highlight advancements in targeting genetic and epigenetic alterations.
- To discuss emerging immunotherapies and cell-engineering techniques.
Main Methods:
- Review of preclinical studies and ongoing clinical trials.
- Analysis of next-generation sequencing data for NB genetic landscape.
- Exploration of targeted drugs, protein degraders, and CAR T/NK cells.
Main Results:
- Next-generation sequencing has improved understanding of NB's genetic and epigenetic profiles.
- Novel treatments target genetic/epigenetic alterations, tumor microenvironment, and immune landscape.
- Immunotherapy and cell-engineering show promise in preclinical and clinical settings.
Conclusions:
- New therapeutic strategies offer hope for improving high-risk neuroblastoma survival.
- Targeted therapies and advanced immunotherapies aim to reduce treatment toxicity.
- Ongoing research and clinical trials are crucial for advancing NB treatment.
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