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Related Experiment Video

Updated: Jun 16, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Short-Term Morphological and Quantitative Changes in Non-Exudative Macular Neovascularization Using Spectral-Domain

Mariachiara Di Pippo¹, Daria Rullo¹, Elisa Maugliani¹

¹Ophthalmology Unit, Neurosciences, Mental Health, and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, University of Rome Sapienza, 00189 Rome, Italy.

Journal of Clinical Medicine

|June 13, 2025

Summary

Optical coherence tomography angiography (OCTA) reveals increasing morphological complexity in non-exudative macular neovascularization (NE-MNV) over six months. This trend suggests a need for closer patient monitoring, particularly for those with higher NE-MNV fractal dimensions.

Keywords:

Image J age-related macular degeneration choroidal vascularity index image processing non-exudative macular neovascularization optical coherence tomography angiography quiescent macular neovascularization retinal imaging spectral-domain optical coherence tomography

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Last Updated: Jun 16, 2025

Author Spotlight: Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

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Published on: May 26, 2023

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

Published on: February 18, 2022

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization

Published on: August 11, 2023

Area of Science:

Ophthalmology
Medical Imaging
Neovascularization Research

Background:

Non-exudative macular neovascularization (NE-MNV) is a key feature in age-related macular degeneration.
Understanding the dynamic changes in NE-MNV morphology is crucial for effective clinical management.

Purpose of the Study:

To evaluate short-term alterations in retinal-choroidal vasculature and NE-MNV morphology.
To utilize optical coherence tomography angiography (OCTA) and spectral-domain optical coherence tomography (SD-OCT) for detailed imaging analysis.

Main Methods:

Sixteen eyes from 12 patients with NE-MNV were examined at baseline and six months.
Quantitative assessment included central macular thickness, foveal avascular zone, vessel density, flow area, choroidal vascularity index, and NE-MNV fractal dimensions.

Main Results:

Significant increases in NE-MNV fractal dimensions, vessel junctions, and vessel length were observed over six months (p < 0.05).
While NE-MNV area increased, this change was not statistically significant.
Standard SD-OCT and OCTA parameters, along with choroidal measurements, showed no significant changes.

Conclusions:

Rising NE-MNV fractal dimensions indicate increased complexity within the neovascular network.
These findings highlight the importance of monitoring NE-MNV complexity for potential clinical implications.
Patients with higher baseline NE-MNV fractal dimensions may require closer follow-up.