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Management of Systemic Cardiotoxicity Associated with Antidepressant Use in Patients with Depressive Disorders: A

Omar Anwar Saleh Al Nakhebi1, Raluka Albu-Kalinovic1, Adela Bosun1

  • 1Doctoral School, University of Medicine and Pharmacy Victor Babes Timisoara, 300041 Timisoara, Romania.

Journal of Clinical Medicine
|June 13, 2025
PubMed

Insights

Antidepressant use is linked to cardiotoxicity, a serious adverse effect. A multidisciplinary approach is crucial for managing and protecting patients from these cardiac risks.

Area of Science:

  • Cardiology
  • Psychiatry
  • Pharmacology

Background:

  • Depression significantly impacts global health and quality of life.
  • Antidepressants are vital for depression treatment but carry risks, including cardiotoxicity.
  • Understanding antidepressant-induced cardiotoxicity is critical for patient safety.

Purpose of the Study:

  • To systematically review and analyze the correlation between antidepressant use and cardiotoxicity.
  • To evaluate the importance of a multidisciplinary approach in managing patients at risk.
  • To inform clinical practice regarding antidepressant-induced cardiac adverse effects.

Main Methods:

  • Systematic literature search adhering to PRISMA guidelines.
  • Inclusion of twenty studies for quantitative analysis.
  • Risk of bias assessment using the Joanna Briggs Institute critical appraisal tool.

Main Results:

  • A significant correlation was identified between antidepressant intake and cardiotoxicity.
  • The necessity of a multidisciplinary strategy for patient protection was highlighted.
  • Pathophysiological mechanisms and therapeutic options were explored.

Conclusions:

  • Effective management of antidepressant-induced cardiotoxicity necessitates understanding its mechanisms.
  • Critical evaluation of therapeutic strategies is essential for clinical practice.
  • A comprehensive approach is vital for mitigating cardiac risks associated with antidepressants.

Keywords:
antidepressive agentscardiotoxicity

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