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Related Concept Videos

Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Dementia01:30

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Alzheimer's Disease: Treatment01:22

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
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  11. Epidemiological Evidence On The Associations Of Metal Exposure With Alzheimer's Disease And Related Dementias Among Elderly Women.
  1. Home
  3. Research Domains
  5. Health Sciences
  7. Epidemiology
  9. Occupational Epidemiology
  11. Epidemiological Evidence On The Associations Of Metal Exposure With Alzheimer's Disease And Related Dementias Among Elderly Women.

Related Experiment Video

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining
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Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

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Epidemiological Evidence on the Associations of Metal Exposure with Alzheimer's Disease and Related Dementias Among Elderly Women.

Fahmida Rashid1, Khalid M Khan1, Samyukthaa Saiprakash2

  • 1Department of Public Health, College of Health Sciences, Sam Houston State University, Texas, TX 77341, USA.

Journal of Clinical Medicine
|June 13, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Heavy metals like copper and lead may increase Alzheimer's risk in women, while selenium and zinc show protective effects. More research is needed to understand these complex relationships for prevention.

Keywords:
ADRDAlzheimer’s diseasedementiaelderly

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Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease
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Author Spotlight: Exploring Sex-Specific Glial Signatures and Therapeutic Leads for Alzheimer's Disease

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Area of Science:

  • Environmental Health
  • Neuroscience
  • Epidemiology

Background:

  • Growing evidence links heavy metals to Alzheimer's disease and related dementias (AD/ADRD).
  • Women face unique AD/ADRD risks, including genetic factors, longer lifespans, and higher depression rates.
  • A sex-specific approach is crucial for understanding women's vulnerability to AD/ADRD.

Purpose of the Study:

  • To review epidemiological evidence on the impact of metals on AD/ADRD in women over the last 11 years.
  • To synthesize findings on specific metal exposures and their association with AD/ADRD risk in the female population.
  • To highlight the need for sex-specific research in environmental neurotoxicology.

Main Methods:

  • Conducted a systematic literature search of PubMed, Google Scholar, NIOSH Toxline, and Scopus (2014-2024).
epidemiological study
heavy metals
women
  • Included primary epidemiological studies focusing on older women exposed to various metals.
  • Analyzed data on associations between metals (e.g., lead, cadmium, arsenic, copper, selenium, iron, zinc) and AD/ADRD risk.

    • Main Results:

    • Identified 34 relevant epidemiological studies.
    • Found significant adverse associations between copper (Cu), cadmium (Cd), arsenic (As), lead (Pb), and manganese (Mn) with AD/ADRD in women.
    • Observed significant protective associations between selenium (Se), iron (Fe), and zinc (Zn) and AD/ADRD risk, though some studies reported no correlation.

    Conclusions:

    • The relationship between metal exposure and AD/ADRD in women is complex, with conflicting results.
    • Certain metals show potential adverse effects, while others may be protective.
    • Further research is essential to clarify these effects and inform preventive strategies for women.