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  11. Clinical Application Of Patient-specific Bolus Based On Molding And Casting Method In Radiotherapy

Clinical Application of Patient-Specific Bolus Based on Molding and Casting Method in Radiotherapy

Jaeman Son1,2, Seonghee Kang1,2, Jegal Jin1,3

  • 1Department of Radiation Oncology, Seoul National University Hospital, Seoul 03080, Republic of Korea.

Journal of Clinical Medicine
|June 13, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

A new mold-and-casting technique using 3D printing and silicone creates patient-specific radiation therapy boluses. This method improves dose delivery precision and uniformity by reducing air gaps, enhancing treatment effectiveness.

Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Biomaterials Engineering

Background:

  • Patient-specific boluses are crucial for precise radiation dose delivery, especially on irregular surfaces.
  • Conventional boluses often result in air gaps and poor conformity, compromising dose distribution.
  • Limitations of traditional boluses necessitate innovative fabrication methods for improved radiation therapy outcomes.

Purpose of the Study:

  • To develop and evaluate a novel patient-specific bolus fabrication method using mold-and-casting (M&C).
  • To integrate 3D printing and flexible silicone materials for enhanced bolus conformity and accuracy.
  • To assess the geometric accuracy, dosimetric performance, and biocompatibility of the novel bolus.

Main Methods:

  • A workflow involving CT imaging, 3D modeling, 3D printed mold fabrication, and silicone casting was employed.
Keywords:
clinical usemolding and castingpatient-specific bolus

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  • Geometric accuracy was evaluated using surface matching and cross-sectional comparisons.
  • In vivo dosimetric performance was assessed with MOSFET detectors, and biocompatibility was tested via standardized protocols.

    • Main Results:

    • The fabricated patient-specific boluses exhibited high geometric fidelity with <3% volumetric and surface discrepancies.
    • Dosimetric evaluations showed maximum dose differences within the clinically acceptable ±5% range.
    • Biocompatibility tests confirmed the safety of the silicone material for clinical use.

    Conclusions:

    • The mold-and-casting (M&C) technique provides a streamlined, clinically integrable method for patient-specific bolus fabrication.
    • This novel approach significantly reduces air gaps and improves surface dose uniformity compared to traditional sheet boluses.
    • The findings support the clinical utility of the M&C method for enhancing precision and efficiency in radiation therapy.