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  3. Corporal Composition And Gut Microbiome Modification Through Exclusion Dietary Intervention In Adult Patients With Crohn's Disease: Protocol For A Prospective, Interventional, Controlled, Randomized Clinical Trial.
  1. Home
  3. Corporal Composition And Gut Microbiome Modification Through Exclusion Dietary Intervention In Adult Patients With Crohn's Disease: Protocol For A Prospective, Interventional, Controlled, Randomized Clinical Trial.

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Corporal Composition and Gut Microbiome Modification Through Exclusion Dietary Intervention in Adult Patients with

Rosario Paloma Cano-Mármol1,2, Virginia Esperanza Fernández-Ruiz1,2, Cristina Martínez-Pascual3

  • 1Department of Endocrinology and Nutrition, Virgen de la Arrixaca University Clinical Hospital, 30120 Murcia, Spain.

Journal of Clinical Medicine
|June 13, 2025

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
Crohn’s diseasecorporal compositionexclusion dietgut microbiome

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This study investigates an exclusion diet supplemented with enteral nutrition for active Crohn's disease (CD) patients. The intervention aims to improve gut health, reduce inflammation, and achieve clinical remission by modifying the gut microbiota.

Area of Science:

  • Gastroenterology
  • Nutritional Science
  • Immunology

Background:

  • Crohn's disease (CD) involves intestinal inflammation, mucosal dysfunction, and gut dysbiosis.
  • Dietary strategies are crucial for managing CD, emphasizing reduced ultra-processed foods and increased anti-inflammatory foods.
  • Current treatments may not suffice for all active CD patients, necessitating novel therapeutic approaches.

Purpose of the Study:

  • To evaluate the efficacy of an exclusion diet with enteral nutrition in adult patients with active CD.
  • To assess the impact of this nutritional intervention on gut microbiota, inflammation, and clinical outcomes.
  • To determine if this diet can induce remission and improve body composition in CD patients.

Main Methods:

  • A prospective, randomized study comparing an exclusion diet with enteral nutrition against standard nutritional recommendations.
  • Participants include active CD patients unresponsive to conventional pharmacological treatment.
  • Outcomes measured include clinical remission (CDAI), inflammatory markers, body composition (BIA), gut microbiota, and quality of life.

    • Main Results:

    • The intervention group is expected to show increased lean body mass and reduced visceral fat.
    • Higher rates of clinical remission and decreased inflammatory markers are anticipated in the intervention group.
    • Improvements in gut microbiota composition and health-related quality of life are predicted.

    Conclusions:

    • An exclusion diet supplemented with enteral nutrition holds potential for treating adult CD patients.
    • This nutritional intervention may effectively modify gut dysbiosis and reduce inflammation.
    • The study hypothesizes significant improvements in clinical, inflammatory, and body composition markers for CD remission.