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Encapsulation of Transforming Growth Factor-β3 in Poly(hydroxybutyrate-co-hydroxyvalerate) Nanoparticles for Enhanced

Ana Isabel Rodríguez-Cendal1,2,3, José Señarís-Rodríguez1,2,3,4, María Piñeiro-Ramil1,2,3

  • 1Universidade da Coruña, Grupo de Investigación en Terapia Celular y Medicina Regenerativa, Departamento de Fisioterapia, Medicina y Ciencias Biomédicas, Facultad de Ciencias de la Salud, 15071 A Coruña, Spain.

International Journal of Molecular Sciences
|June 13, 2025
PubMed
Summary

Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) nanoparticles effectively deliver transforming growth factor β3 (TGF-β3) for cartilage regeneration. This biopolymer drug delivery system promotes extracellular matrix synthesis and mesenchymal stem cell differentiation, offering a single-dose solution.

Keywords:
drug delivery system (DDS)nanoparticles (NPs)poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV)polyhydroxyalkanoate (PHA)regenerative therapy

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