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  11. Vitamin D In The Prevention And Treatment Of Inflammatory Skin Diseases

Vitamin D in the Prevention and Treatment of Inflammatory Skin Diseases

Zrinka Bukvić Mokos1,2, Lucija Tomić Krsnik1, Kristijan Harak1

  • 1Department of Dermatology and Venerology, University Hospital Centre Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia.

International Journal of Molecular Sciences
|June 13, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

Vitamin D is vital for skin health, regulating immune responses and barrier function. Supplementation shows promise for inflammatory skin conditions like psoriasis and acne, though more research is needed.

Area of Science:

  • Dermatology
  • Endocrinology
  • Immunology

Background:

  • Vitamin D, synthesized in skin via UVB, regulates calcium, phosphate, and skin homeostasis.
  • Its active form, 1,25(OH)2D, interacts with the VDR in keratinocytes to control gene expression.
  • Dysregulation of the vitamin D pathway is linked to inflammatory skin diseases.

Purpose of the Study:

  • To review the role of vitamin D in skin physiology and pathology.
  • To integrate molecular mechanisms with clinical findings in dermatological disorders.
  • To highlight the need for further research on vitamin D supplementation strategies.

Main Methods:

  • Literature review integrating molecular mechanisms and clinical findings.
  • Analysis of vitamin D's role in keratinocyte function and immune modulation.
Keywords:
acneatopic dermatitishidradenitis suppurativapsoriasis

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  • Examination of clinical evidence for vitamin D in inflammatory skin diseases.

    • Main Results:

    • Vitamin D modulates skin homeostasis, immune responses, and antimicrobial defense.
    • Implicated in psoriasis, atopic dermatitis, acne, and hidradenitis suppurativa.
    • Topical analogues benefit psoriasis; supplementation shows adjunctive potential in other conditions.

    Conclusions:

    • Vitamin D plays a critical role in cutaneous health and disease.
    • Further research is needed to establish causality and optimize supplementation strategies for dermatological disorders.
    vitamin D