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Roseburia intestinalis Modulates Immune Responses by Inducing M1 Macrophage Polarization
Anna Bircher1, Egle Katkeviciute1, Yasser Morsy1
1Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, 8091 Zurich, Switzerland.
International Journal of Molecular Sciences
|June 13, 2025
Summary
Roseburia intestinalis, a beneficial gut bacterium, shows potential in fighting colorectal cancer (CRC) by activating the immune system. Studies reveal it shifts immune cells towards an anti-tumor M1 phenotype, offering new therapeutic avenues for CRC treatment.
Area of Science:
- Microbiology
- Immunology
- Oncology
Background:
- The gut microbiome plays a role in cancer development, with imbalances observed in colorectal cancer (CRC).
- Beneficial bacteria like Roseburia intestinalis are reduced in CRC patients.
- Previous studies indicated R. intestinalis has anti-tumor effects in mice.
Purpose of the Study:
- To investigate the molecular mechanisms of R. intestinalis in colorectal cancer.
- To highlight the potential therapeutic value of R. intestinalis in CRC.
Main Methods:
- In vitro co-culture experiments with macrophages and cancer cells.
- Analysis of macrophage phenotype (M1/M2) and gene expression.
- Measurement of chemokine and cytokine secretion.
Main Results:
- R. intestinalis exposure increased M1 macrophage phenotype and decreased M2 phenotype.
- Gene expression profiles in macrophages resembled M1 activation.
- Distinct chemokine and cytokine secretion was observed in cancer cells, indicating immune activation.
- No direct cytotoxic effects on cancer cells were observed.
Conclusions:
- R. intestinalis possesses macrophage-polarizing properties, promoting an immune-activating environment.
- The bacterium shows potential for therapeutic use in colorectal cancer by modulating the immune response.
- Further research is needed to explore R. intestinalis's impact on CRC pathogenesis and treatment.
