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Bypass Treatments for Primary Coenzyme Q10 Deficiency: An Update.

International journal of molecular sciences·2026
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Blood-Brain Barrier and Neuronal Model Systems for Studying CoQ<sub>10</sub> Metabolism.

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Secondary Mitochondrial Dysfunction in Gaucher Disease Type I, II and III-Review of the Experimental and Clinical Evidence.

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Coenzyme Q10 and Intracellular Signalling Pathways: Clinical Relevance.

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Gulf War Illness, Fibromyalgia, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID Overlap in Common Symptoms and Underlying Biological Mechanisms: Implications for Future Therapeutic Strategies.

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Ischaemia-Reperfusion Injury in Organ Transplantation: Role of Coenzyme Q10.

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RETRACTED: Kim et al. The Angiogenesis Inhibitor ALS-L1023 from Lemon-Balm Leaves Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease Through Regulating the Visceral Adipose-Tissue Function. <i>Int. J. Mol. Sci.</i> 2017, <i>18</i>, 846.

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Correction: Mahmud et al. Thymoquinone Attenuates NF-κβ Signalling Activation in Retinal Pigment Epithelium Cells Under AMD-Mimicking Conditions. <i>Int. J. Mol. Sci.</i> 2025, <i>26</i>, 11473.

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Related Experiment Video

Updated: Jun 16, 2025

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
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Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Published on: August 16, 2019

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Traumatic Brain Injury and Coenzyme Q10: An Overview.

David Mantle1, Mollie Dewsbury2, Alexander David Mendelow3

  • 1Pharma Nord (UK) Ltd., Morpeth NE61 2DB, UK.

International Journal of Molecular Sciences
|June 13, 2025
PubMed
Summary
This summary is machine-generated.

Supplemental coenzyme Q10 (CoQ10) may offer new therapeutic strategies for traumatic brain injury (TBI). This antioxidant and anti-inflammatory agent shows promise in animal models and may improve TBI patient outcomes by protecting the brain and heart.

Keywords:
coenzyme Q10intranasal drug deliverymitochondrial dysfunctionoxidative stresstraumatic brain injury (TBI)

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Last Updated: Jun 16, 2025

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Pharmacology

Background:

  • Traumatic brain injury (TBI) leads to significant morbidity and mortality.
  • Ischemia, mitochondrial dysfunction, oxidative stress, and inflammation are key contributors to TBI-induced brain damage.
  • Current therapeutic strategies for TBI are insufficient, necessitating novel approaches.

Purpose of the Study:

  • To review the efficacy of supplemental coenzyme Q10 (CoQ10) in animal models of TBI.
  • To explore the potential application of CoQ10 in managing TBI patients.
  • To discuss strategies for overcoming blood-brain barrier limitations for CoQ10 delivery.

Main Methods:

  • Review of existing literature on CoQ10 in TBI animal models.
  • Analysis of CoQ10's biochemical properties as an antioxidant and anti-inflammatory agent.
  • Discussion of intranasal delivery as a method to enhance brain CoQ10 levels.

Main Results:

  • CoQ10 demonstrates potential therapeutic benefits in preclinical TBI models.
  • Intranasal administration may facilitate direct brain access for CoQ10.
  • CoQ10's role in mitigating cardiac dysfunction and immune dysregulation in TBI patients is highlighted.

Conclusions:

  • Supplemental CoQ10 presents a promising therapeutic avenue for TBI management.
  • Targeting mitochondrial dysfunction and oxidative stress with CoQ10 could reduce brain damage.
  • CoQ10 may also prevent cardiovascular complications in TBI patients, improving overall outcomes.