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Drug Discovery: Overview01:26

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Related Experiment Video

Updated: Jun 16, 2025

A Tripeptide-Stabilized Nanoemulsion of Oleic Acid
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Therapeutic Peptides: Recent Advances in Discovery, Synthesis, and Clinical Translation.

Bingyi Zheng1, Xueting Wang1, Meizhai Guo1

  • 1Translational Medicine Research Center, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361005, China.

International Journal of Molecular Sciences
|June 13, 2025
PubMed
Summary

Peptide therapeutics are advancing rapidly due to new production and design methods, overcoming past limitations for use in metabolic disorders, oncology, and infectious diseases.

Keywords:
anticancer peptidesantimicrobial peptidesclinical applicationspeptide discoverypeptide synthesistherapeutic peptides

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Area of Science:

  • Biotechnology
  • Pharmacology
  • Drug Discovery

Background:

  • Peptide therapeutics have faced challenges like poor stability and bioavailability.
  • Recent technological advancements have driven significant progress in peptide drug development.

Purpose of the Study:

  • To review critical developments in peptide drug discovery, production, and clinical applications.
  • To highlight emerging challenges and opportunities in the field.
  • To evaluate the therapeutic potential of peptides for unmet medical needs.

Main Methods:

  • Synthesis of innovations in chemical and biological production.
  • Analysis of novel peptide design and delivery strategies.
  • Review of clinical translation across various therapeutic domains.

Main Results:

  • Breakthroughs in production, modification, and analytical technologies have transformed peptide therapeutics.
  • Historical limitations of peptide drugs have been systematically addressed.
  • Peptides are increasingly characterized and translated for clinical use.

Conclusions:

  • Peptide-based drugs show great promise for treating metabolic disorders, cancer, and infectious diseases.
  • Strategic directions are proposed for integrating peptides into precision medicine.
  • Further research and development are crucial to fully realize the therapeutic potential of peptides.